SHPRH and UBE2N

Data Source:
BioGRID (pull down)

		SHPRH	UBE2N
Description		SNF2 histone linker PHD RING helicase	ubiquitin conjugating enzyme E2 N
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GO Annotations	Cellular Component	Nucleosome Nucleoplasm	Ubiquitin Ligase Complex Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol UBC13-MMS2 Complex Protein-containing Complex UBC13-UEV1A Complex Extracellular Exosome
	Molecular Function	DNA Binding Helicase Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination DNA Repair Nucleosome Assembly Cellular Response To DNA Damage Stimulus Protein Ubiquitination	Activation Of MAPK Activity Protein Polyubiquitination Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Regulation Of DNA Repair Postreplication Repair Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process JNK Cascade Protein Ubiquitination Histone Ubiquitination Positive Regulation Of Histone Modification Regulation Of Histone Ubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of DNA Repair T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	ISG15 antiviral mechanism NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint E3 ubiquitin ligases ubiquitinate target proteins Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Height ( 18391951) Mean reticulocyte volume ( 32888494)
Interacting Genes		10 interacting genes: BORCS6 EDARADD FBXW7 FDFT1 LPP RAD18 UBE2D1 UBE2N UBE2V2 YWHAG	115 interacting genes: AMFR ARIH1 ARIH2 AURKA BARD1 BCL10 BFAR BIRC2 BIRC3 BIRC8 BRCA1 CADPS2 CBL CCNB1 CHFR CHUK CNOT4 DTL DTX1 DZIP3 F12 HERC2 HSP90AA1 LNX1 LRSAM1 MALT1 MARCHF5 MARCHF7 MDM2 MIB1 MIB2 MID1 MKRN3 MUL1 MYLIP NBN NEDD4L NEURL1 NFX1 OTUB1 OTUB2 PEDS1 PEDS1-UBE2V1 PELI1 PELI3 PJA2 PRKN PTTG1 RBCK1 RC3H1 RC3H2 RFFL RFWD3 RIPK1 RNF103 RNF11 RNF111 RNF115 RNF122 RNF125 RNF126 RNF128 RNF13 RNF130 RNF135 RNF152 RNF165 RNF167 RNF181 RNF182 RNF38 RNF4 RNF43 RNF5 RNF8 SH3RF1 SH3RF2 SHPRH SIAH1 SIAH2 SLC2A4 STUB1 TNFAIP3 TOPORS TP53 TRAF2 TRAF6 TRIM14 TRIM17 TRIM21 TRIM23 TRIM25 TRIM27 TRIM28 TRIM32 TRIM33 TRIM39 TRIM5 TRIM50 TRIM54 TRIM63 TRIM69 TRIM72 UBA1 UBB UBC UBE2V1 UBE2V2 UBE3A UHRF1 XIAP ZNRF1 ZNRF2 ZNRF3 ZNRF4
Entrez ID		257218	7334
HPRD ID		10476	04725
Ensembl ID		ENSG00000146414	ENSG00000177889
Uniprot IDs		B3KX98 Q149N8	P61088 V9HW41
PDB IDs		2M85 4QN1	1J7D 2C2V 3HCT 3HCU 3VON 3W31 4DHI 4DHJ 4DHZ 4IP3 4NR3 4NRG 4NRI 4ONL 4ONM 4ONN 4ORH 4TKP 4WHV 5AIT 5AIU 5EYA 5H7S 5VNZ 5VO0 5YWR 6D6I 6JKY 6KFP 6KG6 6KL4 6P5B 6S53 6ULH 6UMP 6UMS 7BXG
Enriched GO Terms of Interacting Partners?
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