PPP2R5C and PPP1CC

Data Source:
BioGRID (two hybrid)

		PPP2R5C	PPP1CC
Description		protein phosphatase 2 regulatory subunit B'gamma	protein phosphatase 1 catalytic subunit gamma
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Nucleoplasm Golgi Apparatus Cytosol	Protein Phosphatase Type 1 Complex Condensed Chromosome Kinetochore Chromosome, Telomeric Region Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Focal Adhesion Nuclear Speck Midbody Cleavage Furrow Protein-containing Complex Dendritic Spine PTW/PP1 Phosphatase Complex Presynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Lamin Binding Protein C-terminus Binding Protein Phosphatase 1 Binding Phosphatase Activity Protein Kinase Binding Protein Domain Specific Binding Protein-containing Complex Binding Metal Ion Binding Protein N-terminus Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Protein Dephosphorylation Signal Transduction Negative Regulation Of Cell Population Proliferation Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Protein Autophosphorylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Protein Kinase B Signaling	Glycogen Metabolic Process Protein Dephosphorylation Cell Cycle Neuron Differentiation Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Regulation Of Nucleocytoplasmic Transport Cell Division Positive Regulation Of Glial Cell Proliferation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Triglyceride catabolism Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Circadian Clock RHO GTPases Activate Formins RAF activation Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Signaling by MRAS-complex mutants
Drugs		2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid	9,10-Deepithio-9,10-Didehydroacanthifolicin Calyculin A Motuporin
Diseases
GWAS		Anti-saccade response ( 29064472) Autism ( 20663923) Leukoderma in response to rhododendrol ( 32558222) Metabolite levels ( 23823483)	Heart rate ( 23583979)
Interacting Genes		18 interacting genes: APP ATM AXIN1 BRCA1 CHEK2 EP300 IER3 MAPK1 MBP PAXIP1 PPP1CA PPP1CB PPP1CC PPP2CA PPP2R1B PRKCD PXN SGO1	131 interacting genes: AATK ABT1 ACAD8 AKAP11 ANKRD42 APIP APP ASH2L AURKA B4GAT1 BMPR2 BTBD10 C14orf180 C1QA C9orf50 CEP126 CLMN CLOCK CLTC CNST COPS5 CSNK1A1 CSNK1E CSNK2B CSRNP1 CSRNP2 CTSL CYFIP1 DACT1 DEAF1 DELEC1 DYNLT4 DYRK4 EIF2AK2 ELP4 ENKD1 FBXW11 FTL FXYD6 GLB1L GOLGA7 GSTZ1 HCFC1 HDAC6 HMGN1 IFTAP IL3RA INSYN1 JAK2 KCTD20 KDM4D KRCC1 LMTK2 MAP4K4 MAPT MYO16 NAPEPLD NEK2 NMT2 NONO NRBP1 NUAK1 PHACTR4 PHC1 PIAS1 POLR1F PPP1R11 PPP1R15B PPP1R16A PPP1R18 PPP1R2 PPP1R2B PPP1R2C PPP1R32 PPP1R35 PPP1R3A PPP1R3B PPP1R3C PPP1R3D PPP1R7 PPP1R8 PPP1R9A PPP1R9B PPP2R5C PRR16 RAF1 RB1 RIF1 RNF19B RORC RPL7 RPRD2 RRM1 RRP1B SDR39U1 SFRP1 SGCE SH3RF2 SHANK3 SMARCB1 SMG6 SPATC1L SPOCD1 STAM STARD9 STAU1 SUMO2 TACC2 TBC1D19 TEFM TEX36 TLX1 TLX3 TMEM120A TNS1 TOPBP1 TOR1AIP1 TP53 TP53BP2 TPRN TRA2A VSTM4 WBP11 YLPM1 YWHAZ ZDBF2 ZFYVE9 ZNF24 ZNF318 ZNF629 ZNF667
Entrez ID		5527	5501
HPRD ID		03385	08911
Ensembl ID		ENSG00000078304	ENSG00000186298
Uniprot IDs		Q13362	A0A024RBP2 P36873
PDB IDs		2IAE 2JAK 2NPP 2NYL 2NYM 3FGA 5JJA 5K6S 5SW9 5SWF 6OYL 6TOQ 6VOY 6VRO 6Z2Y	1IT6 1JK7 1U32 2BCD 2BDX 4UT2 4UT3 5INB 5J28
Enriched GO Terms of Interacting Partners?
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