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PPP1CC and HDAC6
Data Source:
BioGRID
(pull down)
PPP1CC
HDAC6
Description
protein phosphatase 1 catalytic subunit gamma
histone deacetylase 6
Image
GO Annotations
Cellular Component
Protein Phosphatase Type 1 Complex
Condensed Chromosome Kinetochore
Chromosome, Telomeric Region
Nucleus
Nucleolus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Focal Adhesion
Nuclear Speck
Midbody
Cleavage Furrow
Protein-containing Complex
Dendritic Spine
PTW/PP1 Phosphatase Complex
Presynapse
Glutamatergic Synapse
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Cytoplasm
Multivesicular Body
Cytosol
Microtubule
Microtubule Associated Complex
Caveola
Inclusion Body
Aggresome
Dynein Complex
Axon
Dendrite
Cell Leading Edge
Perikaryon
Perinuclear Region Of Cytoplasm
Molecular Function
RNA Binding
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Binding
Lamin Binding
Protein C-terminus Binding
Protein Phosphatase 1 Binding
Phosphatase Activity
Protein Kinase Binding
Protein Domain Specific Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein N-terminus Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Corepressor Binding
Actin Binding
Histone Deacetylase Activity
Protein Binding
Beta-catenin Binding
Microtubule Binding
Zinc Ion Binding
Enzyme Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Histone Deacetylase Binding
Tubulin Deacetylase Activity
Alpha-tubulin Binding
Ubiquitin Binding
Acetylspermidine Deacetylase Activity
Tau Protein Binding
Beta-tubulin Binding
Misfolded Protein Binding
Hsp90 Protein Binding
Dynein Complex Binding
Biological Process
Glycogen Metabolic Process
Protein Dephosphorylation
Cell Cycle
Neuron Differentiation
Circadian Regulation Of Gene Expression
Regulation Of Circadian Rhythm
Entrainment Of Circadian Clock By Photoperiod
Regulation Of Nucleocytoplasmic Transport
Cell Division
Positive Regulation Of Glial Cell Proliferation
Protein Polyubiquitination
Protein Deacetylation
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
Intracellular Protein Transport
Autophagy
Negative Regulation Of Microtubule Depolymerization
Regulation Of Autophagy
Positive Regulation Of Epithelial Cell Migration
Negative Regulation Of Hydrogen Peroxide Metabolic Process
Regulation Of Macroautophagy
Histone Deacetylation
Negative Regulation Of Protein-containing Complex Assembly
Regulation Of Protein Stability
Protein Destabilization
Lysosome Localization
Protein-containing Complex Disassembly
Positive Regulation Of Peptidyl-serine Phosphorylation
Peptidyl-lysine Deacetylation
Cellular Response To Topologically Incorrect Protein
Regulation Of Gene Expression, Epigenetic
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Negative Regulation Of Protein-containing Complex Disassembly
Regulation Of Fat Cell Differentiation
Negative Regulation Of Proteolysis
Negative Regulation Of Transcription, DNA-templated
Collateral Sprouting
Negative Regulation Of Oxidoreductase Activity
Mitochondrion Localization
Response To Misfolded Protein
Cilium Assembly
Regulation Of Microtubule-based Movement
Regulation Of Androgen Receptor Signaling Pathway
Dendritic Spine Morphogenesis
Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization
Regulation Of Establishment Of Protein Localization
Cellular Response To Hydrogen Peroxide
Aggresome Assembly
Polyubiquitinated Misfolded Protein Transport
Hsp90 Deacetylation
Response To Growth Factor
Histone H3 Deacetylation
Cellular Response To Misfolded Protein
Tubulin Deacetylation
Polyamine Deacetylation
Spermidine Deacetylation
Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Signaling Receptor Activity
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Triglyceride catabolism
Downregulation of TGF-beta receptor signaling
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Circadian Clock
RHO GTPases Activate Formins
RAF activation
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Signaling by MRAS-complex mutants
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HSF1 activation
Notch-HLH transcription pathway
Cilium Assembly
Transcriptional regulation by RUNX2
RUNX2 regulates osteoblast differentiation
Chaperone Mediated Autophagy
Late endosomal microautophagy
Aggrephagy
Aggrephagy
Drugs
9,10-Deepithio-9,10-Didehydroacanthifolicin
Calyculin A
Motuporin
Vorinostat
Belinostat
Pracinostat
Romidepsin
Panobinostat
Bufexamac
Diseases
GWAS
Heart rate (
23583979
)
Interacting Genes
131 interacting genes:
AATK
ABT1
ACAD8
AKAP11
ANKRD42
APIP
APP
ASH2L
AURKA
B4GAT1
BMPR2
BTBD10
C14orf180
C1QA
C9orf50
CEP126
CLMN
CLOCK
CLTC
CNST
COPS5
CSNK1A1
CSNK1E
CSNK2B
CSRNP1
CSRNP2
CTSL
CYFIP1
DACT1
DEAF1
DELEC1
DYNLT4
DYRK4
EIF2AK2
ELP4
ENKD1
FBXW11
FTL
FXYD6
GLB1L
GOLGA7
GSTZ1
HCFC1
HDAC6
HMGN1
IFTAP
IL3RA
INSYN1
JAK2
KCTD20
KDM4D
KRCC1
LMTK2
MAP4K4
MAPT
MYO16
NAPEPLD
NEK2
NMT2
NONO
NRBP1
NUAK1
PHACTR4
PHC1
PIAS1
POLR1F
PPP1R11
PPP1R15B
PPP1R16A
PPP1R18
PPP1R2
PPP1R2B
PPP1R2C
PPP1R32
PPP1R35
PPP1R3A
PPP1R3B
PPP1R3C
PPP1R3D
PPP1R7
PPP1R8
PPP1R9A
PPP1R9B
PPP2R5C
PRR16
RAF1
RB1
RIF1
RNF19B
RORC
RPL7
RPRD2
RRM1
RRP1B
SDR39U1
SFRP1
SGCE
SH3RF2
SHANK3
SMARCB1
SMG6
SPATC1L
SPOCD1
STAM
STARD9
STAU1
SUMO2
TACC2
TBC1D19
TEFM
TEX36
TLX1
TLX3
TMEM120A
TNS1
TOPBP1
TOR1AIP1
TP53
TP53BP2
TPRN
TRA2A
VSTM4
WBP11
YLPM1
YWHAZ
ZDBF2
ZFYVE9
ZNF24
ZNF318
ZNF629
ZNF667
83 interacting genes:
ADRB2
APOBEC3G
ARHGDIA
ATF3
ATXN3
AURKA
BBS10
BCL3
BCOR
BRMS1
CDKN1A
CEP70
CSNK2A2
CTTN
CYLD
DYNLL2
EGFR
EP300
ERBB2
ERBB3
ERBB4
FBP1
FBXO11
FNTA
FNTB
GRK2
H3C1
H4-16
HDAC11
HES1
HSP90AA1
HTATIP2
HTATSF1
ISG15
JDP2
KPNA1
LCOR
LPXN
MAPK1
MAPK3
MAPT
MLH1
MSH2
NACAD
NASP
NR0B2
NR3C1
PLAA
POLA2
POLDIP2
POLR1B
PPP1CC
PRDX4
PRKCZ
PRKN
PROM1
PTOV1
PXN
RELB
RNF31
RUNX2
SEPTIN7
SIRT2
SYK
TPPP
TRIM50
TUBA1A
TUBA1B
TUBA4A
TUBB
TUBB2A
TUBB2B
UBB
UBC
UBE2D1
UBE2D3
UBE2E1
UBE2H
VCP
VKORC1
YWHAZ
ZBTB16
ZNF205
Entrez ID
5501
10013
HPRD ID
08911
02228
Ensembl ID
ENSG00000186298
ENSG00000094631
Uniprot IDs
A0A024RBP2
P36873
A0A024QZ26
B4DZH6
Q9BRX7
Q9NSW6
Q9UBN7
PDB IDs
1IT6
1JK7
1U32
2BCD
2BDX
4UT2
4UT3
5INB
5J28
3C5K
3GV4
3PHD
5B8D
5EDU
5KH3
5KH7
5KH9
5WBN
5WPB
6CE6
6CE8
6CEA
6CEC
6CED
6CEE
6CEF
Enriched GO Terms of Interacting Partners
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