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PPP2R5C and SGO1
Data Source:
HPRD
(in vivo)
PPP2R5C
SGO1
Description
protein phosphatase 2 regulatory subunit B'gamma
shugoshin 1
Image
GO Annotations
Cellular Component
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Nucleus
Nucleoplasm
Golgi Apparatus
Cytosol
Chromosome, Centromeric Region
Kinetochore
Condensed Chromosome Kinetochore
Condensed Chromosome, Centromeric Region
Spindle Pole
Nucleoplasm
Centrosome
Cytosol
Molecular Function
Protein Binding
Protein Phosphatase Regulator Activity
Protein Phosphatase Activator Activity
Protein Binding
Kinase Binding
Biological Process
Protein Dephosphorylation
Signal Transduction
Negative Regulation Of Cell Population Proliferation
Regulation Of Phosphatidylinositol 3-kinase Signaling
Regulation Of Protein Autophosphorylation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Phosphoprotein Phosphatase Activity
Negative Regulation Of Protein Kinase B Signaling
Mitotic Sister Chromatid Segregation
Chromosome Segregation
Attachment Of Spindle Microtubules To Kinetochore
Centriole-centriole Cohesion
Meiotic Chromosome Segregation
Homologous Chromosome Segregation
Meiotic Sister Chromatid Cohesion
Cell Division
Mitotic Sister Chromatid Cohesion, Centromeric
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Drugs
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS
Anti-saccade response (
29064472
)
Autism (
20663923
)
Leukoderma in response to rhododendrol (
32558222
)
Metabolite levels (
23823483
)
Interacting Genes
18 interacting genes:
APP
ATM
AXIN1
BRCA1
CHEK2
EP300
IER3
MAPK1
MBP
PAXIP1
PPP1CA
PPP1CB
PPP1CC
PPP2CA
PPP2R1B
PRKCD
PXN
SGO1
20 interacting genes:
CDCA8
LRRC59
PPP2CA
PPP2CB
PPP2R1A
PPP2R1B
PPP2R5A
PPP2R5B
PPP2R5C
PPP2R5D
PPP2R5E
PRKDC
RPL10A
RPL28
RPL7
RPL7A
RPLP1
SET
XRCC5
XRCC6
Entrez ID
5527
151648
HPRD ID
03385
12377
Ensembl ID
ENSG00000078304
ENSG00000129810
Uniprot IDs
Q13362
A0A024R2J4
B5BUA4
Q5FBB7
PDB IDs
2IAE
2JAK
2NPP
2NYL
2NYM
3FGA
5JJA
5K6S
5SW9
5SWF
6OYL
6TOQ
6VOY
6VRO
6Z2Y
3FGA
3Q6S
4A0I
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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