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PPP1CC and SH3RF2
Data Source:
BioGRID
(two hybrid, two hybrid)
PPP1CC
SH3RF2
Description
protein phosphatase 1 catalytic subunit gamma
SH3 domain containing ring finger 2
Image
No pdb structure
GO Annotations
Cellular Component
Protein Phosphatase Type 1 Complex
Condensed Chromosome Kinetochore
Chromosome, Telomeric Region
Nucleus
Nucleolus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Focal Adhesion
Nuclear Speck
Midbody
Cleavage Furrow
Protein-containing Complex
Dendritic Spine
PTW/PP1 Phosphatase Complex
Presynapse
Glutamatergic Synapse
Nucleus
Nucleoplasm
Molecular Function
RNA Binding
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Binding
Lamin Binding
Protein C-terminus Binding
Protein Phosphatase 1 Binding
Phosphatase Activity
Protein Kinase Binding
Protein Domain Specific Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein N-terminus Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Protein Phosphatase Inhibitor Activity
Protein Binding
Protein Phosphatase 1 Binding
Phosphatase Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Glycogen Metabolic Process
Protein Dephosphorylation
Cell Cycle
Neuron Differentiation
Circadian Regulation Of Gene Expression
Regulation Of Circadian Rhythm
Entrainment Of Circadian Clock By Photoperiod
Regulation Of Nucleocytoplasmic Transport
Cell Division
Positive Regulation Of Glial Cell Proliferation
Negative Regulation Of Phosphatase Activity
Positive Regulation Of Cell Migration
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Phosphoprotein Phosphatase Activity
Negative Regulation Of Apoptotic Process
Negative Regulation Of JNK Cascade
Positive Regulation Of JNK Cascade
Protein Autoubiquitination
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Triglyceride catabolism
Downregulation of TGF-beta receptor signaling
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Circadian Clock
RHO GTPases Activate Formins
RAF activation
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Signaling by MRAS-complex mutants
Drugs
9,10-Deepithio-9,10-Didehydroacanthifolicin
Calyculin A
Motuporin
Diseases
GWAS
Heart rate (
23583979
)
Bacteremia (
27236921
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Response to (pegylated) interferon in HBeAG-positive hepatitis B (
30715261
)
Interacting Genes
131 interacting genes:
AATK
ABT1
ACAD8
AKAP11
ANKRD42
APIP
APP
ASH2L
AURKA
B4GAT1
BMPR2
BTBD10
C14orf180
C1QA
C9orf50
CEP126
CLMN
CLOCK
CLTC
CNST
COPS5
CSNK1A1
CSNK1E
CSNK2B
CSRNP1
CSRNP2
CTSL
CYFIP1
DACT1
DEAF1
DELEC1
DYNLT4
DYRK4
EIF2AK2
ELP4
ENKD1
FBXW11
FTL
FXYD6
GLB1L
GOLGA7
GSTZ1
HCFC1
HDAC6
HMGN1
IFTAP
IL3RA
INSYN1
JAK2
KCTD20
KDM4D
KRCC1
LMTK2
MAP4K4
MAPT
MYO16
NAPEPLD
NEK2
NMT2
NONO
NRBP1
NUAK1
PHACTR4
PHC1
PIAS1
POLR1F
PPP1R11
PPP1R15B
PPP1R16A
PPP1R18
PPP1R2
PPP1R2B
PPP1R2C
PPP1R32
PPP1R35
PPP1R3A
PPP1R3B
PPP1R3C
PPP1R3D
PPP1R7
PPP1R8
PPP1R9A
PPP1R9B
PPP2R5C
PRR16
RAF1
RB1
RIF1
RNF19B
RORC
RPL7
RPRD2
RRM1
RRP1B
SDR39U1
SFRP1
SGCE
SH3RF2
SHANK3
SMARCB1
SMG6
SPATC1L
SPOCD1
STAM
STARD9
STAU1
SUMO2
TACC2
TBC1D19
TEFM
TEX36
TLX1
TLX3
TMEM120A
TNS1
TOPBP1
TOR1AIP1
TP53
TP53BP2
TPRN
TRA2A
VSTM4
WBP11
YLPM1
YWHAZ
ZDBF2
ZFYVE9
ZNF24
ZNF318
ZNF629
ZNF667
23 interacting genes:
AKAP8L
AMOTL2
APP
ATXN7L2
BAG4
BANP
CBY2
CCDC102B
CYSRT1
EFS
FASLG
GOLGA2
HOMEZ
LMNA
LZTS2
MTUS2
NEK6
PAK4
PPP1CA
PPP1CC
RBPMS
UBE2N
VPS37C
Entrez ID
5501
153769
HPRD ID
08911
10229
Ensembl ID
ENSG00000186298
ENSG00000156463
Uniprot IDs
A0A024RBP2
P36873
Q08AM8
Q8TEC5
PDB IDs
1IT6
1JK7
1U32
2BCD
2BDX
4UT2
4UT3
5INB
5J28
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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