Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
PPP2CB and ICOSLG
Data Source:
BioGRID
(affinity chromatography technology)
PPP2CB
ICOSLG
Description
protein phosphatase 2 catalytic subunit beta
inducible T cell costimulator ligand
Image
No pdb structure
GO Annotations
Cellular Component
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Spindle Pole
Nucleus
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Integral Component Of Membrane
Cytoplasmic Ribonucleoprotein Granule
Extracellular Exosome
Molecular Function
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein C-terminus Binding
Metal Ion Binding
Tau Protein Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Signaling Receptor Binding
Protein Binding
Identical Protein Binding
Biological Process
Protein Dephosphorylation
Apoptotic Mitochondrial Changes
Response To Lead Ion
Regulation Of Gene Expression
Response To Endoplasmic Reticulum Stress
Peptidyl-threonine Dephosphorylation
Response To Hydrogen Peroxide
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Ras Protein Signal Transduction
Response To Antibiotic
Peptidyl-serine Dephosphorylation
Positive Regulation Of Microtubule Binding
Regulation Of Cytokine Production
Adaptive Immune Response
Defense Response
Hyperosmotic Response
Signal Transduction
T Cell Costimulation
Positive Regulation Of Activated T Cell Proliferation
T Cell Activation
B Cell Activation
T Cell Receptor Signaling Pathway
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Integration of energy metabolism
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Costimulation by the CD28 family
Drugs
Vitamin E
Diseases
GWAS
Daytime sleep phenotypes (
27126917
)
Ankylosing spondylitis (
23749187
)
Blood protein levels (
30072576
29875488
)
Celiac disease (
22057235
20190752
)
Cerebral amyloid deposition (PET imaging) (
30361487
)
Crohn's disease (
18587394
21102463
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Inflammatory bowel disease (
23128233
)
Left ventricular QRS voltage (
27195777
)
Rheumatoid arthritis (
30423114
)
Type 1 diabetes (
25751624
)
Ulcerative colitis (
21297633
)
Interacting Genes
41 interacting genes:
ACP5
AURKA
AXIN1
BHLHE41
BUB1
C22orf39
DOCK7
DYNLT2B
EGFR
GAD1
GSTA1
HK3
KRAS
LCMT1
MAK
MAPT
MID1
MLH1
MLH3
NRAS
PACS1
PDGFRL
PLXNA3
PMS2
PRKCB
PTPRJ
RAF1
RELA
RPLP1
SGO1
SMAD4
SRC
STK11
TAB1
TAB2
TGFBR2
TIPRL
TLX1
TRMT61B
ZFP28
ZNF775
1 interacting genes:
ICOS
Entrez ID
5516
23308
HPRD ID
01487
05757
Ensembl ID
ENSG00000104695
ENSG00000160223
Uniprot IDs
A0A140VJS0
P62714
A0N0L8
B7Z1W8
O75144
PDB IDs
6X4G
6X4T
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?