ICOSLG

Description		inducible T cell costimulator ligand
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Cytokine Production Adaptive Immune Response Defense Response Hyperosmotic Response Signal Transduction T Cell Costimulation Positive Regulation Of Activated T Cell Proliferation T Cell Activation B Cell Activation T Cell Receptor Signaling Pathway
Pathways		Costimulation by the CD28 family
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Blood protein levels ( 30072576 29875488) Celiac disease ( 22057235 20190752) Cerebral amyloid deposition (PET imaging) ( 30361487) Crohn's disease ( 18587394 21102463) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 23128233) Left ventricular QRS voltage ( 27195777) Rheumatoid arthritis ( 30423114) Type 1 diabetes ( 25751624) Ulcerative colitis ( 21297633)
Novel Interacting Genes		6 novel interacting genes: BACE2 DIP2A PPP2CB SGO1 SH3GLB1 SLC27A2
Interacting Genes		1 interacting genes: ICOS
Entrez ID		23308
HPRD ID		05757
Ensembl ID		ENSG00000160223
Uniprot IDs		A0N0L8 B7Z1W8 O75144
PDB IDs		6X4G 6X4T
Enriched GO Terms of Interacting Partners?
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