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PPP2CB and PTPRJ
Data Source:
BioGRID
(two hybrid)
PPP2CB
PTPRJ
Description
protein phosphatase 2 catalytic subunit beta
protein tyrosine phosphatase receptor type J
Image
No pdb structure
GO Annotations
Cellular Component
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Spindle Pole
Nucleus
Cytosol
Immunological Synapse
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
Cell Surface
Ruffle Membrane
Specific Granule Membrane
Extracellular Exosome
Molecular Function
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein C-terminus Binding
Metal Ion Binding
Tau Protein Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Beta-catenin Binding
Phosphatase Activity
Protein Kinase Binding
Gamma-catenin Binding
Cadherin Binding
Mitogen-activated Protein Kinase Binding
Delta-catenin Binding
Biological Process
Protein Dephosphorylation
Apoptotic Mitochondrial Changes
Response To Lead Ion
Regulation Of Gene Expression
Response To Endoplasmic Reticulum Stress
Peptidyl-threonine Dephosphorylation
Response To Hydrogen Peroxide
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Ras Protein Signal Transduction
Response To Antibiotic
Peptidyl-serine Dephosphorylation
Positive Regulation Of Microtubule Binding
Protein Dephosphorylation
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Regulation Of Cell Adhesion
B Cell Differentiation
Negative Regulation Of Cell Growth
Negative Regulation Of Cell Migration
Positive Regulation Of Tumor Necrosis Factor Production
Peptidyl-tyrosine Dephosphorylation
Calcium-mediated Signaling Using Intracellular Calcium Source
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Vascular Permeability
Neutrophil Degranulation
Negative Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cell Adhesion
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
T Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Receptor Signaling Pathway
Positive Chemotaxis
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Protein Kinase B Signaling
Contact Inhibition
Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Integration of energy metabolism
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Phosphorylation of CD3 and TCR zeta chains
Neutrophil degranulation
Negative regulation of MET activity
Negative regulation of FLT3
Drugs
Vitamin E
Diseases
GWAS
Daytime sleep phenotypes (
27126917
)
Acute lymphoblastic leukemia (childhood) (
22076464
)
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Blood protein levels (
30072576
)
D-dimer levels (
21502573
)
Experiencing mood swings (
29500382
)
Heel bone mineral density (
30598549
)
Height (
28552196
25282103
23563607
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Hypertension (
31879980
)
Intraocular pressure (
29617998
25173106
31798171
29785010
31959993
30054594
29235454
)
Lymphocyte counts (
32888494
)
Mean platelet volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte count (
32888494
)
Offspring birth weight (
31043758
)
Refractive error (
32231278
)
Sleep duration (short sleep) (
30846698
)
Interacting Genes
41 interacting genes:
ACP5
AURKA
AXIN1
BHLHE41
BUB1
C22orf39
DOCK7
DYNLT2B
EGFR
GAD1
GSTA1
HK3
KRAS
LCMT1
MAK
MAPT
MID1
MLH1
MLH3
NRAS
PACS1
PDGFRL
PLXNA3
PMS2
PRKCB
PTPRJ
RAF1
RELA
RPLP1
SGO1
SMAD4
SRC
STK11
TAB1
TAB2
TGFBR2
TIPRL
TLX1
TRMT61B
ZFP28
ZNF775
36 interacting genes:
ANP32B
BAAT
BAP1
CASC3
CTNNB1
CTNND1
CYP17A1
EGFR
EPSTI1
FANCC
FBP1
HEMGN
HOXC6
HRAS
IL2RG
JUP
KLK7
KLK9
LAT
LYPD3
MAP2K1
MET
NANS
NOP2
PDGFRB
PLCG1
PPP2CB
PPP3R2
PRDM14
RASA1
SDCBP
SFRP4
TMEFF1
TRMO
TSTD2
ZNF510
Entrez ID
5516
5795
HPRD ID
01487
02955
Ensembl ID
ENSG00000104695
ENSG00000149177
Uniprot IDs
A0A140VJS0
P62714
Q12913
Q9NPR5
PDB IDs
2CFV
2DLE
2NZ6
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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