PPP2CB and TAB2

Data Source:
BioGRID (two hybrid)

		PPP2CB	TAB2
Description		protein phosphatase 2 catalytic subunit beta	TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Spindle Pole Nucleus Cytosol	Nucleoplasm Cytosol Plasma Membrane Endosome Membrane
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Protein C-terminus Binding Metal Ion Binding Tau Protein Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Binding Ubiquitin Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Protein Dephosphorylation Apoptotic Mitochondrial Changes Response To Lead Ion Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress Peptidyl-threonine Dephosphorylation Response To Hydrogen Peroxide Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ras Protein Signal Transduction Response To Antibiotic Peptidyl-serine Dephosphorylation Positive Regulation Of Microtubule Binding	Activation Of MAPK Activity Stimulatory C-type Lectin Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Heart Development Negative Regulation Of Autophagy Response To Lipopolysaccharide Fc-epsilon Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Integration of energy metabolism PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation	Nuclear signaling by ERBB4 Nuclear signaling by ERBB4 NOD1/2 Signaling Pathway Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NFkappaB signaling pathway CLEC7A (Dectin-1) signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs		Vitamin E
Diseases
GWAS		Daytime sleep phenotypes ( 27126917)	Breast cancer ( 22383897 29059683) Coronary artery disease ( 33020668) Diverticulitis ( 28585551) Dupuytren's disease ( 28886342 21732829) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		41 interacting genes: ACP5 AURKA AXIN1 BHLHE41 BUB1 C22orf39 DOCK7 DYNLT2B EGFR GAD1 GSTA1 HK3 KRAS LCMT1 MAK MAPT MID1 MLH1 MLH3 NRAS PACS1 PDGFRL PLXNA3 PMS2 PRKCB PTPRJ RAF1 RELA RPLP1 SGO1 SMAD4 SRC STK11 TAB1 TAB2 TGFBR2 TIPRL TLX1 TRMT61B ZFP28 ZNF775	43 interacting genes: APP CAMK2A CST9L EIF2AK2 EMILIN1 ERBB4 FN1 FOSL1 GTF2I HDAC1 HDAC3 HDAC5 HSF2BP IKBKB IKBKG IRAK1 KRT85 MAP3K7 NCOR1 NFKB1 NR2C2 NUMBL PPIL3 PPP2CB SLC19A3 TAB1 TBL1X TGM2 TNFRSF11A TPM3 TRAF2 TRAF3IP1 TRAF6 TTN UBC UBE2I VIM VPS52 XIAP YWHAZ ZBTB16 ZFP64 ZNF143
Entrez ID		5516	23118
HPRD ID		01487	05483
Ensembl ID		ENSG00000104695	ENSG00000055208
Uniprot IDs		A0A140VJS0 P62714	B4DIR9 Q9NYJ8
PDB IDs			2DAE 2WWZ 2WX0 2WX1
Enriched GO Terms of Interacting Partners?
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