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PPP2CB and PLXNA3
Data Source:
BioGRID
(two hybrid)
PPP2CB
PLXNA3
Description
protein phosphatase 2 catalytic subunit beta
plexin A3
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Spindle Pole
Nucleus
Cytosol
Semaphorin Receptor Complex
Plasma Membrane
Integral Component Of Plasma Membrane
Membrane
Molecular Function
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein C-terminus Binding
Metal Ion Binding
Tau Protein Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Transmembrane Signaling Receptor Activity
Protein Binding
Semaphorin Receptor Activity
Biological Process
Protein Dephosphorylation
Apoptotic Mitochondrial Changes
Response To Lead Ion
Regulation Of Gene Expression
Response To Endoplasmic Reticulum Stress
Peptidyl-threonine Dephosphorylation
Response To Hydrogen Peroxide
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Ras Protein Signal Transduction
Response To Antibiotic
Peptidyl-serine Dephosphorylation
Positive Regulation Of Microtubule Binding
Negative Regulation Of Cell Adhesion
Multicellular Organism Development
Regulation Of Cell Shape
Facial Nerve Structural Organization
Trigeminal Nerve Structural Organization
Hippocampus Development
Branchiomotor Neuron Axon Guidance
Pyramidal Neuron Development
Regulation Of Cell Migration
Regulation Of GTPase Activity
Negative Regulation Of Axon Extension Involved In Axon Guidance
Positive Regulation Of Axonogenesis
Negative Chemotaxis
Positive Regulation Of Cytoskeleton Organization
Semaphorin-plexin Signaling Pathway
Semaphorin-plexin Signaling Pathway Involved In Axon Guidance
Neuron Projection Extension
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Integration of energy metabolism
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
Drugs
Vitamin E
Diseases
GWAS
Daytime sleep phenotypes (
27126917
)
Interacting Genes
41 interacting genes:
ACP5
AURKA
AXIN1
BHLHE41
BUB1
C22orf39
DOCK7
DYNLT2B
EGFR
GAD1
GSTA1
HK3
KRAS
LCMT1
MAK
MAPT
MID1
MLH1
MLH3
NRAS
PACS1
PDGFRL
PLXNA3
PMS2
PRKCB
PTPRJ
RAF1
RELA
RPLP1
SGO1
SMAD4
SRC
STK11
TAB1
TAB2
TGFBR2
TIPRL
TLX1
TRMT61B
ZFP28
ZNF775
8 interacting genes:
CSNK2B
MAPK8IP2
MTDH
PPP2CB
SMN1
TK1
TRIM55
TRIM63
Entrez ID
5516
55558
HPRD ID
01487
02062
Ensembl ID
ENSG00000104695
ENSG00000130827
Uniprot IDs
A0A140VJS0
P62714
P51805
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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