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PPP2CB and C22orf39
Data Source:
BioGRID
(two hybrid)
PPP2CB
C22orf39
Description
protein phosphatase 2 catalytic subunit beta
chromosome 22 open reading frame 39
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Spindle Pole
Nucleus
Cytosol
Molecular Function
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein C-terminus Binding
Metal Ion Binding
Tau Protein Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Protein Binding
Biological Process
Protein Dephosphorylation
Apoptotic Mitochondrial Changes
Response To Lead Ion
Regulation Of Gene Expression
Response To Endoplasmic Reticulum Stress
Peptidyl-threonine Dephosphorylation
Response To Hydrogen Peroxide
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Ras Protein Signal Transduction
Response To Antibiotic
Peptidyl-serine Dephosphorylation
Positive Regulation Of Microtubule Binding
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Integration of energy metabolism
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Drugs
Vitamin E
Diseases
GWAS
Daytime sleep phenotypes (
27126917
)
Interacting Genes
41 interacting genes:
ACP5
AURKA
AXIN1
BHLHE41
BUB1
C22orf39
DOCK7
DYNLT2B
EGFR
GAD1
GSTA1
HK3
KRAS
LCMT1
MAK
MAPT
MID1
MLH1
MLH3
NRAS
PACS1
PDGFRL
PLXNA3
PMS2
PRKCB
PTPRJ
RAF1
RELA
RPLP1
SGO1
SMAD4
SRC
STK11
TAB1
TAB2
TGFBR2
TIPRL
TLX1
TRMT61B
ZFP28
ZNF775
42 interacting genes:
ANKS1A
BANP
CABP2
CEP76
COL8A1
CRYBA2
CYSRT1
DTX2
EXOSC8
FRS3
GNE
GRN
HSD3B7
ID2
ID3
INCA1
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-8
KRTAP10-9
KRTAP12-3
KRTAP13-2
KRTAP9-2
MAGEA11
MAPK8IP2
MDFI
MGAT5B
NFATC2IP
PCSK5
PFDN5
PLSCR3
PPP2CB
PSMA1
RBPMS
RECK
RIMBP3C
SNX32
SYCE1L
TRIB3
VWC2L
ZNF620
Entrez ID
5516
128977
HPRD ID
01487
14041
Ensembl ID
ENSG00000104695
ENSG00000242259
Uniprot IDs
A0A140VJS0
P62714
Q6P5X5
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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