USP47 and AP4M1

Data Source:
BioGRID (two hybrid)

		USP47	AP4M1
Description		ubiquitin specific peptidase 47	adaptor related protein complex 4 subunit mu 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Early Endosome Trans-Golgi Network Cytosol AP-4 Adaptor Complex Clathrin Adaptor Complex Cytoplasmic Vesicle Endosome Lumen Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding WD40-repeat Domain Binding Ubiquitinyl Hydrolase Activity	Protein Binding Protein Domain Specific Binding
	Biological Process	Base-excision Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Deubiquitination Protein Phosphopantetheinylation Positive Regulation Of Cell Growth Regulation Of Protein Stability Cellular Response To UV Monoubiquitinated Protein Deubiquitination Response To Drug Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Protein Targeting Protein Targeting To Lysosome Intracellular Protein Transport Golgi To Endosome Transport Protein Localization Vesicle-mediated Transport Golgi To Lysosome Transport Protein Localization To Basolateral Plasma Membrane
Pathways		Ub-specific processing proteases	Lysosome Vesicle Biogenesis
Drugs
Diseases			Cerebral palsy
GWAS		Waist circumference adjusted for body mass index ( 28552196)	Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		6 interacting genes: AP4M1 MED29 MED9 PLA2G2A SNCA UBC	14 interacting genes: AP4B1 ARF1 CACNG3 CD63 CHTF8 DDX52 FNTA GRID2 GRIN2A GRIN2B LAMP2 TGOLN2 USP47 ZBTB22
Entrez ID		55031	9179
HPRD ID		11668	03803
Ensembl ID		ENSG00000170242	ENSG00000221838
Uniprot IDs		Q68D97 Q96K76	C9JC87 O00189
PDB IDs			3L81 4MDR
Enriched GO Terms of Interacting Partners?
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