H1-5 and LOX

Data Source:
HPRD (in vitro)

		H1-5	LOX
Description		H1.5 linker histone, cluster member	lysyl oxidase
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleosome Heterochromatin Nucleus	Extracellular Region Collagen Trimer Extracellular Space Nucleus Extracellular Matrix
	Molecular Function	Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding Histone Deacetylase Binding	Protein-lysine 6-oxidase Activity Copper Ion Binding Protein Binding Collagen Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Nucleosome Positioning Chromosome Condensation Positive Regulation Of Cell Growth Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination Protein Stabilization Positive Regulation Of Histone H3-K9 Methylation Establishment Of Protein Localization To Chromatin	Osteoblast Differentiation Regulation Of Protein Phosphorylation Cellular Protein Modification Process Heart Development Regulation Of Gene Expression Regulation Of Striated Muscle Tissue Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-lysine Oxidation Protein Phosphopantetheinylation Extracellular Matrix Organization Collagen Fibril Organization Bone Mineralization Lung Development Platelet-derived Growth Factor Receptor-beta Signaling Pathway Ascending Aorta Development Descending Aorta Development Wound Healing Response To Drug Regulation Of Apoptotic Process Protein Kinase B Signaling Regulation Of Megakaryocyte Differentiation Muscle Cell Cellular Homeostasis Elastic Fiber Assembly Blood Vessel Morphogenesis Response To Steroid Hormone Muscle Fiber Development Cell Chemotaxis Connective Tissue Development DNA Biosynthetic Process Regulation Of Receptor Binding Regulation Of Bone Development Cellular Response To Chemokine Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	Elastic fibre formation Crosslinking of collagen fibrils
Drugs
Diseases
GWAS			Central corneal thickness ( 32528159) Coronary artery disease ( 28714974) Intraocular pressure ( 29617998) Lung function (FEV1/FVC) ( 30804560) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		31 interacting genes: CBX5 CCNA1 CCNA2 CCNB1 CCNE1 CDC42 CDK1 CDK2 CDK5 CDKN1A CDKN1B EHMT2 HPF1 IRAK4 KAT2A KAT2B L3MBTL1 LOX MELK MLLT1 NSD1 PARP1 PARP2 PRKCA PRKCB PRKCD PRKCZ RIPK3 RPS6KA5 SERPINH1 SIRT1	8 interacting genes: DHDDS DPT ELN H1-1 H1-5 H2BC11 H2BC21 RAF1
Entrez ID		3009	4015
HPRD ID		00821	01087
Ensembl ID		ENSG00000184357	ENSG00000113083
Uniprot IDs		P16401	B0AZT2 B7ZAJ4 D0PNI2 P28300
PDB IDs		2FE2 2RHI
Enriched GO Terms of Interacting Partners?
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