H1-5 and HPF1

Data Source:
BioGRID (pull down)

		H1-5	HPF1
Description		H1.5 linker histone, cluster member	histone PARylation factor 1
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GO Annotations	Cellular Component	Chromatin Nucleosome Heterochromatin Nucleus	Nucleus
	Molecular Function	Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding Histone Deacetylase Binding	Protein Binding Zinc Ion Binding Histone Binding Poly-ADP-D-ribose Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Nucleosome Positioning Chromosome Condensation Positive Regulation Of Cell Growth Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination Protein Stabilization Positive Regulation Of Histone H3-K9 Methylation Establishment Of Protein Localization To Chromatin	Cellular Response To DNA Damage Stimulus Regulation Of Protein ADP-ribosylation Peptidyl-serine ADP-ribosylation
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS
Interacting Genes		31 interacting genes: CBX5 CCNA1 CCNA2 CCNB1 CCNE1 CDC42 CDK1 CDK2 CDK5 CDKN1A CDKN1B EHMT2 HPF1 IRAK4 KAT2A KAT2B L3MBTL1 LOX MELK MLLT1 NSD1 PARP1 PARP2 PRKCA PRKCB PRKCD PRKCZ RIPK3 RPS6KA5 SERPINH1 SIRT1	15 interacting genes: EIF6 FBXO7 H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HMGA1 HMGB1 HMGN1 HMGN2 HMGN4 PARP1 PARP2
Entrez ID		3009	54969
HPRD ID		00821	07924
Ensembl ID		ENSG00000184357	ENSG00000056050
Uniprot IDs		P16401	Q9NWY4
PDB IDs		2FE2 2RHI	6TX2 6TX3 6X0L 6X0M 6X0N
Enriched GO Terms of Interacting Partners?
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