TENT5C and PLK4

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TENT5C	PLK4
Description		terminal nucleotidyltransferase 5C	polo like kinase 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Spindle Pole XY Body Nucleus Nucleolus Cytoplasm Centrosome Centriole Cytosol Cleavage Furrow Deuterosome
	Molecular Function	RNA Binding Protein Binding RNA Adenylyltransferase Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	In Utero Embryonic Development Viral Process MRNA Stabilization	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cytokinesis Positive Regulation Of Centriole Replication Trophoblast Giant Cell Differentiation Ciliary Basal Body-plasma Membrane Docking De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs			Fostamatinib
Diseases
GWAS
Interacting Genes		7 interacting genes: AP2B1 DAZAP2 MVP PLK4 PRKN RHOXF2 TRIP6	22 interacting genes: ARR3 BTRC C1orf109 CHD3 CYLD DNAJB13 ELOA GAS8 MTUS2 OSBPL3 PRDM16 SFN SMAD4 SPAG5 TAX1BP3 TEC TENT5B TENT5C TFIP11 TGFBR1 TRIM54 ZBTB39
Entrez ID		54855	10733
HPRD ID		13312	10387
Ensembl ID		ENSG00000183508	ENSG00000142731
Uniprot IDs		Q5VWP2	O00444
PDB IDs		6W36 6W38 6W3I 6W3J	2N19 3COK 4JXF 4N7V 4N7Z 4N9J 4YUR 4YYP 5LHY 5LHZ 6N45 6N46 6W38 6W3I 6W3J
Enriched GO Terms of Interacting Partners?
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