PROM1 and HDAC6

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		PROM1	HDAC6
Description		prominin 1	histone deacetylase 6
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cilium Cell Surface Apical Plasma Membrane Microvillus Membrane Vesicle Photoreceptor Outer Segment Membrane Extracellular Exosome Prominosome	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Multivesicular Body Cytosol Microtubule Microtubule Associated Complex Caveola Inclusion Body Aggresome Dynein Complex Axon Dendrite Cell Leading Edge Perikaryon Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Cholesterol Binding Actinin Binding Cadherin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Corepressor Binding Actin Binding Histone Deacetylase Activity Protein Binding Beta-catenin Binding Microtubule Binding Zinc Ion Binding Enzyme Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding Tubulin Deacetylase Activity Alpha-tubulin Binding Ubiquitin Binding Acetylspermidine Deacetylase Activity Tau Protein Binding Beta-tubulin Binding Misfolded Protein Binding Hsp90 Protein Binding Dynein Complex Binding
	Biological Process	Retina Layer Formation Photoreceptor Cell Maintenance Retina Morphogenesis In Camera-type Eye Camera-type Eye Photoreceptor Cell Differentiation Glomerular Visceral Epithelial Cell Differentiation Glomerular Parietal Epithelial Cell Differentiation Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation	Protein Polyubiquitination Protein Deacetylation Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Intracellular Protein Transport Autophagy Negative Regulation Of Microtubule Depolymerization Regulation Of Autophagy Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Macroautophagy Histone Deacetylation Negative Regulation Of Protein-containing Complex Assembly Regulation Of Protein Stability Protein Destabilization Lysosome Localization Protein-containing Complex Disassembly Positive Regulation Of Peptidyl-serine Phosphorylation Peptidyl-lysine Deacetylation Cellular Response To Topologically Incorrect Protein Regulation Of Gene Expression, Epigenetic Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Fat Cell Differentiation Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Collateral Sprouting Negative Regulation Of Oxidoreductase Activity Mitochondrion Localization Response To Misfolded Protein Cilium Assembly Regulation Of Microtubule-based Movement Regulation Of Androgen Receptor Signaling Pathway Dendritic Spine Morphogenesis Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization Regulation Of Establishment Of Protein Localization Cellular Response To Hydrogen Peroxide Aggresome Assembly Polyubiquitinated Misfolded Protein Transport Hsp90 Deacetylation Response To Growth Factor Histone H3 Deacetylation Cellular Response To Misfolded Protein Tubulin Deacetylation Polyamine Deacetylation Spermidine Deacetylation Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Signaling Receptor Activity
Pathways			NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HSF1 activation Notch-HLH transcription pathway Cilium Assembly Transcriptional regulation by RUNX2 RUNX2 regulates osteoblast differentiation Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs			Vorinostat Belinostat Pracinostat Romidepsin Panobinostat Bufexamac
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD) Stargardt disease (STGD); Fundus flavimaculatus Retinitis pigmentosa (RP)
GWAS		Dental caries ( 23064961) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glomerular filtration rate in chronic kidney disease ( 26420894) Intracranial aneurysm ( 29531279) Pulse pressure ( 30224653) Self-rated health ( 20707712) Suicide attempts in depression or bipolar disorder ( 24964207)
Interacting Genes		4 interacting genes: HDAC6 PIK3R1 PLEKHA5 SRC	83 interacting genes: ADRB2 APOBEC3G ARHGDIA ATF3 ATXN3 AURKA BBS10 BCL3 BCOR BRMS1 CDKN1A CEP70 CSNK2A2 CTTN CYLD DYNLL2 EGFR EP300 ERBB2 ERBB3 ERBB4 FBP1 FBXO11 FNTA FNTB GRK2 H3C1 H4-16 HDAC11 HES1 HSP90AA1 HTATIP2 HTATSF1 ISG15 JDP2 KPNA1 LCOR LPXN MAPK1 MAPK3 MAPT MLH1 MSH2 NACAD NASP NR0B2 NR3C1 PLAA POLA2 POLDIP2 POLR1B PPP1CC PRDX4 PRKCZ PRKN PROM1 PTOV1 PXN RELB RNF31 RUNX2 SEPTIN7 SIRT2 SYK TPPP TRIM50 TUBA1A TUBA1B TUBA4A TUBB TUBB2A TUBB2B UBB UBC UBE2D1 UBE2D3 UBE2E1 UBE2H VCP VKORC1 YWHAZ ZBTB16 ZNF205
Entrez ID		8842	10013
HPRD ID		05079	02228
Ensembl ID		ENSG00000007062	ENSG00000094631
Uniprot IDs		A0A0A0N0M1 O43490	A0A024QZ26 B4DZH6 Q9BRX7 Q9NSW6 Q9UBN7
PDB IDs			3C5K 3GV4 3PHD 5B8D 5EDU 5KH3 5KH7 5KH9 5WBN 5WPB 6CE6 6CE8 6CEA 6CEC 6CED 6CEE 6CEF
Enriched GO Terms of Interacting Partners?
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