RNF216 and USP5

Data Source:
BioGRID (two hybrid)

		RNF216	USP5
Description		ring finger protein 216	ubiquitin specific peptidase 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Schaffer Collateral - CA1 Synapse Postsynaptic Endocytic Zone Glutamatergic Synapse	Nucleus Lysosome Cytosol
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Ubiquitin Binding
	Biological Process	Apoptotic Process Viral Process Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination Protein Catabolic Process, Modulating Synaptic Transmission	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination
Pathways		Negative regulators of DDX58/IFIH1 signaling	Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Diseases
GWAS			Refractive error ( 32231278)
Interacting Genes		30 interacting genes: AGFG1 BRCA1 CAPN15 FAM168A KIR2DL4 MAPK1 MORC3 OPTN RIPK1 RNF11 SUMO2 TLR3 TLR4 TLR5 TLR9 TNFAIP3 TRAF3 UBAC1 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L3 UBE2L6 USP5 YOD1 ZFAND2A	26 interacting genes: APP DAZAP2 DVL2 PJA1 PLA2G2A RFFL RNF11 RNF216 SMURF1 SPART STK33 SUMO2 TADA3 TMEM239 TRIM26 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIML1 UBC UBE2S UBTD2 USP28
Entrez ID		54476	8078
HPRD ID		15550	03265
Ensembl ID		ENSG00000011275	ENSG00000111667
Uniprot IDs		A8K8N1 Q9NWF9	A0A140VJZ1 P45974
PDB IDs			2DAG 2DAK 2G43 2G45 3IHP 6DXH 6DXT 6NFT 6P9G
Enriched GO Terms of Interacting Partners?
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