USP5 and STK33

Data Source:
BioGRID (pull down)

		USP5	STK33
Description		ubiquitin specific peptidase 5	serine/threonine kinase 33
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Lysosome Cytosol	Nucleus Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Ubiquitin Binding	Protein Serine/threonine Kinase Activity ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination	Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Protein Autophosphorylation
Pathways		Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs			Fostamatinib
Diseases
GWAS		Refractive error ( 32231278)	Adult body size ( 32376654) Body mass index ( 26426971 19079261 28892062 28448500) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body mass index x sex x age interaction (4df test) ( 26426971) Fruit consumption ( 32066663) Intake of total sugars ( 31005972) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Small cell lung carcinoma ( 28604730)
Interacting Genes		26 interacting genes: APP DAZAP2 DVL2 PJA1 PLA2G2A RFFL RNF11 RNF216 SMURF1 SPART STK33 SUMO2 TADA3 TMEM239 TRIM26 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIML1 UBC UBE2S UBTD2 USP28	5 interacting genes: APP GLYCTK HPD USP15 USP5
Entrez ID		8078	65975
HPRD ID		03265	09642
Ensembl ID		ENSG00000111667	ENSG00000130413
Uniprot IDs		A0A140VJZ1 P45974	B3KS39 B4DDH2 F8WAK5 Q9BYT3
PDB IDs		2DAG 2DAK 2G43 2G45 3IHP 6DXH 6DXT 6NFT 6P9G
Enriched GO Terms of Interacting Partners?
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