RNF216 and TLR5

Data Source:
HPRD (two hybrid)

		RNF216	TLR5
Description		ring finger protein 216	toll like receptor 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Schaffer Collateral - CA1 Synapse Postsynaptic Endocytic Zone Glutamatergic Synapse	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Binding Protein Binding Signaling Receptor Activity
	Biological Process	Apoptotic Process Viral Process Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination Protein Catabolic Process, Modulating Synaptic Transmission	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Positive Regulation Of Interleukin-8 Production Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Defense Response To Bacterium Innate Immune Response Cellular Response To Mechanical Stimulus
Pathways		Negative regulators of DDX58/IFIH1 signaling	Toll Like Receptor 5 (TLR5) Cascade MyD88 deficiency (TLR5) IRAK4 deficiency (TLR5) MyD88 cascade initiated on plasma membrane
Drugs
Diseases			Systemic lupus erythematosus
GWAS			Monocyte percentage of white cells ( 32888494)
Interacting Genes		30 interacting genes: AGFG1 BRCA1 CAPN15 FAM168A KIR2DL4 MAPK1 MORC3 OPTN RIPK1 RNF11 SUMO2 TLR3 TLR4 TLR5 TLR9 TNFAIP3 TRAF3 UBAC1 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L3 UBE2L6 USP5 YOD1 ZFAND2A	5 interacting genes: MYD88 RNF216 SIGIRR TLR1 TLR4
Entrez ID		54476	7100
HPRD ID		15550	04326
Ensembl ID		ENSG00000011275	ENSG00000187554
Uniprot IDs		A8K8N1 Q9NWF9	A0A2R8Y7Z4 O60602
PDB IDs			1P95 3J0A
Enriched GO Terms of Interacting Partners?
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