DPM3 and FAM177A1

Data Source:
BioGRID (two hybrid)

		DPM3	FAM177A1
Description		dolichyl-phosphate mannosyltransferase subunit 3, regulatory	family with sequence similarity 177 member A1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane Mannosyltransferase Complex Dolichol-phosphate-mannose Synthase Complex
	Molecular Function	Protein Binding Enzyme Activator Activity
	Biological Process	Carbohydrate Metabolic Process GPI Anchor Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Protein C-linked Glycosylation Via 2'-alpha-mannosyl-L-tryptophan Regulation Of Protein Stability Protein Mannosylation Protein O-linked Mannosylation Regulation Of Catalytic Activity
Pathways		Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate in non-diabetics ( 31451708) Inflammatory bowel disease ( 28067908) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Prostate cancer ( 23535732) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31578528) Urinary albumin-to-creatinine ratio ( 31630189)	Bipolar disorder lithium response (continuous) or schizophrenia ( 29121268) Blood protein levels ( 30072576 29875488) Circulating fibroblast growth factor 23 levels ( 30217807) Colorectal carcinoma in primary sclerosing cholangitis ( 28779025) Lymphocyte counts ( 32888494 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		6 interacting genes: DPM1 DPM2 FAM177A1 IER3IP1 SEC22B TMEM147	8 interacting genes: AQP6 DPM3 ELOVL4 FATE1 JAGN1 PBX3 SGPL1 TMX2
Entrez ID		54344	283635
HPRD ID		16179	12644
Ensembl ID		ENSG00000179085	ENSG00000151327
Uniprot IDs		A0A140VJI4 Q86TM7 Q9P2X0	Q8N128
PDB IDs
Enriched GO Terms of Interacting Partners?
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