DPM3 and DPM1

Data Source:
HPRD (in vivo)

		DPM3	DPM1
Description		dolichyl-phosphate mannosyltransferase subunit 3, regulatory	dolichyl-phosphate mannosyltransferase subunit 1, catalytic
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane Mannosyltransferase Complex Dolichol-phosphate-mannose Synthase Complex	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex
	Molecular Function	Protein Binding Enzyme Activator Activity	Dolichyl-phosphate-mannose-protein Mannosyltransferase Activity Dolichyl-phosphate Beta-D-mannosyltransferase Activity Protein Binding
	Biological Process	Carbohydrate Metabolic Process GPI Anchor Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Protein C-linked Glycosylation Via 2'-alpha-mannosyl-L-tryptophan Regulation Of Protein Stability Protein Mannosylation Protein O-linked Mannosylation Regulation Of Catalytic Activity	GPI Anchor Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Dolichol Metabolic Process Protein Mannosylation Protein O-linked Mannosylation
Pathways		Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)	Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate in non-diabetics ( 31451708) Inflammatory bowel disease ( 28067908) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Prostate cancer ( 23535732) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31578528) Urinary albumin-to-creatinine ratio ( 31630189)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)
Interacting Genes		6 interacting genes: DPM1 DPM2 FAM177A1 IER3IP1 SEC22B TMEM147	7 interacting genes: DPM2 DPM3 MEOX2 MTNR1A PTEN TDO2 ZBTB16
Entrez ID		54344	8813
HPRD ID		16179	04613
Ensembl ID		ENSG00000179085	ENSG00000000419
Uniprot IDs		A0A140VJI4 Q86TM7 Q9P2X0	A0A0S2Z4Y5 O60762 Q5QPK2
PDB IDs
Enriched GO Terms of Interacting Partners?
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