FAM177A1 and DPM3

Data Source:
BioGRID (two hybrid)

		FAM177A1	DPM3
Description		family with sequence similarity 177 member A1	dolichyl-phosphate mannosyltransferase subunit 3, regulatory
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane Mannosyltransferase Complex Dolichol-phosphate-mannose Synthase Complex
	Molecular Function		Protein Binding Enzyme Activator Activity
	Biological Process		Carbohydrate Metabolic Process GPI Anchor Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Protein C-linked Glycosylation Via 2'-alpha-mannosyl-L-tryptophan Regulation Of Protein Stability Protein Mannosylation Protein O-linked Mannosylation Regulation Of Catalytic Activity
Pathways			Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)
Drugs
Diseases
GWAS		Bipolar disorder lithium response (continuous) or schizophrenia ( 29121268) Blood protein levels ( 30072576 29875488) Circulating fibroblast growth factor 23 levels ( 30217807) Colorectal carcinoma in primary sclerosing cholangitis ( 28779025) Lymphocyte counts ( 32888494 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate in non-diabetics ( 31451708) Inflammatory bowel disease ( 28067908) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Prostate cancer ( 23535732) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31578528) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		8 interacting genes: AQP6 DPM3 ELOVL4 FATE1 JAGN1 PBX3 SGPL1 TMX2	6 interacting genes: DPM1 DPM2 FAM177A1 IER3IP1 SEC22B TMEM147
Entrez ID		283635	54344
HPRD ID		12644	16179
Ensembl ID		ENSG00000151327	ENSG00000179085
Uniprot IDs		Q8N128	A0A140VJI4 Q86TM7 Q9P2X0
PDB IDs
Enriched GO Terms of Interacting Partners?
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