DPM3 and TMEM147

Data Source:
BioGRID (two hybrid)

		DPM3	TMEM147
Description		dolichyl-phosphate mannosyltransferase subunit 3, regulatory	transmembrane protein 147
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane Mannosyltransferase Complex Dolichol-phosphate-mannose Synthase Complex	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Protein-containing Complex
	Molecular Function	Protein Binding Enzyme Activator Activity	Protein Binding
	Biological Process	Carbohydrate Metabolic Process GPI Anchor Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Protein C-linked Glycosylation Via 2'-alpha-mannosyl-L-tryptophan Regulation Of Protein Stability Protein Mannosylation Protein O-linked Mannosylation Regulation Of Catalytic Activity
Pathways		Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate in non-diabetics ( 31451708) Inflammatory bowel disease ( 28067908) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Prostate cancer ( 23535732) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31578528) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		6 interacting genes: DPM1 DPM2 FAM177A1 IER3IP1 SEC22B TMEM147	54 interacting genes: ABHD16A ABI3 CD40 CD79A CLDN7 CLN8 CLRN1 CREB3L1 CXCR2 DPM3 EBP EFNA4 ENPP4 F11R FFAR2 GJA8 GLP1R GOLM1 GPR101 GPR37L1 GPR42 GPR61 HTR2C IL3RA KASH5 LDLRAD1 LEUTX LHFPL2 MTIF3 MUC1 PACC1 PDCD1LG2 PSCA PVR RMDN3 RNF185 SCAMP4 SHISA3 SLC10A1 SLC12A7 SLC13A4 SLC22A1 SLC22A2 SUSD3 SYNE4 TACR1 TEX29 TMEM14B TMEM237 TMEM248 TMEM252 TMEM42 TMEM52B TSPAN12
Entrez ID		54344	10430
HPRD ID		16179	17633
Ensembl ID		ENSG00000179085	ENSG00000105677
Uniprot IDs		A0A140VJI4 Q86TM7 Q9P2X0	Q9BVK8
PDB IDs			6W6L
Enriched GO Terms of Interacting Partners?
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