FAM177A1 and SGPL1

Data Source:
BioGRID (two hybrid)

		FAM177A1	SGPL1
Description		family with sequence similarity 177 member A1	sphingosine-1-phosphate lyase 1
Image		No pdb structure
GO Annotations	Cellular Component		Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function		Protein Binding Sphinganine-1-phosphate Aldolase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding
	Biological Process		Luteinization Vasculogenesis Ameboidal-type Cell Migration Kidney Development Fatty Acid Metabolic Process Ceramide Metabolic Process Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Post-embryonic Development Fibroblast Migration Hemopoiesis Sphingolipid Biosynthetic Process Sphingolipid Catabolic Process Leydig Cell Differentiation Regulation Of Multicellular Organism Growth Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Roof Of Mouth Development Face Morphogenesis Apoptotic Signaling Pathway
Pathways			Sphingolipid de novo biosynthesis
Drugs			Pyridoxal phosphate
Diseases
GWAS		Bipolar disorder lithium response (continuous) or schizophrenia ( 29121268) Blood protein levels ( 30072576 29875488) Circulating fibroblast growth factor 23 levels ( 30217807) Colorectal carcinoma in primary sclerosing cholangitis ( 28779025) Lymphocyte counts ( 32888494 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Metabolite levels ( 23823483) Microalbuminuria ( 26631737) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		8 interacting genes: AQP6 DPM3 ELOVL4 FATE1 JAGN1 PBX3 SGPL1 TMX2	35 interacting genes: AQP3 AQP9 BCL2L2 BRICD5 CCL4L2 CLDN19 EFNA5 ERG28 FA2H FAM177A1 FXYD3 HMOX2 IFITM3 MARCHF5 MFSD6 MIP MMD2 PAQR5 PLP2 PLPP4 RNASE10 RTP2 SCAMP5 SLC30A3 SRPK2 STATH STING1 STX4 STX8 TMEM176A TMEM242 TMEM97 TRARG1 TSPAN4 UNC50
Entrez ID		283635	8879
HPRD ID		12644	07224
Ensembl ID		ENSG00000151327	ENSG00000166224
Uniprot IDs		Q8N128	O95470
PDB IDs			4Q6R
Enriched GO Terms of Interacting Partners?
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