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POLR2B and MEN1
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
POLR2B
MEN1
Description
RNA polymerase II subunit B
menin 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
RNA Polymerase II, Core Complex
Membrane
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum Lumen
Cytosol
Nuclear Matrix
Cleavage Furrow
Protein-containing Complex
Histone Methyltransferase Complex
Molecular Function
RNA Polymerase II Activity
DNA Binding
Chromatin Binding
RNA Binding
DNA-directed 5'-3' RNA Polymerase Activity
Protein Binding
Ribonucleoside Binding
Metal Ion Binding
Four-way Junction DNA Binding
Y-form DNA Binding
Transcription Regulatory Region Sequence-specific DNA Binding
Chromatin Binding
Double-stranded DNA Binding
Protein Binding
Histone-lysine N-methyltransferase Activity
Protein-macromolecule Adaptor Activity
Protein N-terminus Binding
R-SMAD Binding
Biological Process
MRNA Splicing, Via Spliceosome
Transcription-coupled Nucleotide-excision Repair
Transcription, DNA-templated
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Fibroblast Growth Factor Receptor Signaling Pathway
RNA Metabolic Process
Somatic Stem Cell Population Maintenance
SnRNA Transcription By RNA Polymerase II
Positive Regulation Of Viral Transcription
Regulation Of Gene Silencing By MiRNA
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Negative Regulation Of Protein Phosphorylation
Osteoblast Development
DNA Repair
Regulation Of Transcription By RNA Polymerase II
Cellular Response To DNA Damage Stimulus
Negative Regulation Of Cell Population Proliferation
Response To UV
Response To Gamma Radiation
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Protein Binding
Histone Lysine Methylation
Negative Regulation Of DNA-binding Transcription Factor Activity
Post-translational Protein Modification
Cellular Protein Metabolic Process
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of JNK Cascade
Negative Regulation Of Telomerase Activity
Beta-catenin-TCF Complex Assembly
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
MicroRNA (miRNA) biogenesis
Transcriptional regulation by small RNAs
PIWI-interacting RNA (piRNA) biogenesis
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression
Inhibition of DNA recombination at telomere
Formation of the beta-catenin:TCF transactivating complex
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Deactivation of the beta-catenin transactivating complex
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
RHO GTPases activate IQGAPs
Post-translational protein phosphorylation
Drugs
Diseases
Carcinoid
Adrenal carcinoma
Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT)
Malignant islet cell carcinoma
GWAS
Age-related macular degeneration (
21909106
)
Bitter alcoholic beverage consumption (
31046077
)
Congenital heart disease (maternal effect) (
28468790
)
Coronary artery disease (
29212778
)
Height (
20881960
25429064
)
Metabolite levels (
23823483
)
White blood cell count (
29403010
)
Urate levels (
21768215
)
Interacting Genes
20 interacting genes:
BTF3
CALM1
CCNH
CDK7
CTDP1
IKBKG
ITCH
LZTR1
MEN1
NEDD4
OTUD5
POLR2C
POLR2D
POLR2H
POLR2K
POLR2L
PTEN
SNAR-B2
SUB1
ZSCAN1
32 interacting genes:
ASH2L
CTNNB1
DAXX
DBF4
ESR1
FANCD2
FOXN3
GFAP
H3-4
HDAC1
HDAC2
IQGAP1
JUND
KMT2A
KMT2D
MYC
MYH9
NFKB1
NFKB2
POLR2B
RBBP5
RELA
RPA2
SIN3A
SMAD1
SMAD3
SMAD5
SNW1
TCF3
TCF7L2
TP53
VIM
Entrez ID
5431
4221
HPRD ID
15943
00564
Ensembl ID
ENSG00000047315
ENSG00000133895
Uniprot IDs
B4DH29
B4DHJ3
C9J2Y9
P30876
A0A024R5D2
A0A024R5E3
A0A5F9ZHS3
O00255
Q9GZQ5
PDB IDs
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
6DRD
6O9L
3U84
3U85
3U86
3U88
4GPQ
4GQ3
4GQ4
4GQ6
4I80
4OG3
4OG4
4OG5
4OG6
4OG7
4OG8
4X5Y
4X5Z
5DB0
5DB1
5DB2
5DB3
5DD9
5DDA
5DDB
5DDC
5DDD
5DDE
5DDF
6B41
6BXH
6BXY
6BY8
6E1A
6O5I
6OPJ
6PKC
6WNH
Enriched GO Terms of Interacting Partners
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