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POLR2B and OTUD5
Data Source:
BioGRID
(pull down)
POLR2B
OTUD5
Description
RNA polymerase II subunit B
OTU deubiquitinase 5
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
RNA Polymerase II, Core Complex
Membrane
Cytosol
Molecular Function
RNA Polymerase II Activity
DNA Binding
Chromatin Binding
RNA Binding
DNA-directed 5'-3' RNA Polymerase Activity
Protein Binding
Ribonucleoside Binding
Metal Ion Binding
Thiol-dependent Ubiquitin-specific Protease Activity
Cysteine-type Peptidase Activity
Lys63-specific Deubiquitinase Activity
Ubiquitinyl Hydrolase Activity
Lys48-specific Deubiquitinase Activity
Biological Process
MRNA Splicing, Via Spliceosome
Transcription-coupled Nucleotide-excision Repair
Transcription, DNA-templated
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Fibroblast Growth Factor Receptor Signaling Pathway
RNA Metabolic Process
Somatic Stem Cell Population Maintenance
SnRNA Transcription By RNA Polymerase II
Positive Regulation Of Viral Transcription
Regulation Of Gene Silencing By MiRNA
Protein Deubiquitination
Protein Phosphopantetheinylation
Negative Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
Protein K63-linked Deubiquitination
Protein K48-linked Deubiquitination
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
MicroRNA (miRNA) biogenesis
Transcriptional regulation by small RNAs
PIWI-interacting RNA (piRNA) biogenesis
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression
Inhibition of DNA recombination at telomere
Ovarian tumor domain proteases
Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS
Age-related macular degeneration (
21909106
)
Bitter alcoholic beverage consumption (
31046077
)
Congenital heart disease (maternal effect) (
28468790
)
Coronary artery disease (
29212778
)
Height (
20881960
25429064
)
Metabolite levels (
23823483
)
White blood cell count (
29403010
)
Interacting Genes
20 interacting genes:
BTF3
CALM1
CCNH
CDK7
CTDP1
IKBKG
ITCH
LZTR1
MEN1
NEDD4
OTUD5
POLR2C
POLR2D
POLR2H
POLR2K
POLR2L
PTEN
SNAR-B2
SUB1
ZSCAN1
12 interacting genes:
ARPC3
NEDD8
NONO
PDCD5
POLR2A
POLR2B
POLR2C
SUB1
TP53
TRAF3
UBC
UBR5
Entrez ID
5431
55593
HPRD ID
15943
06488
Ensembl ID
ENSG00000047315
ENSG00000068308
Uniprot IDs
B4DH29
B4DHJ3
C9J2Y9
P30876
A0A024QZ09
Q96G74
PDB IDs
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
6DRD
6O9L
3PFY
3TMO
3TMP
Enriched GO Terms of Interacting Partners
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