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UPF1 and UPF3A
Data Source:
HPRD
(in vivo)
UPF1
UPF3A
Description
UPF1 RNA helicase and ATPase
UPF3A regulator of nonsense mediated mRNA decay
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
P-body
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Exon-exon Junction Complex
Supraspliceosomal Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Exon-exon Junction Complex
Intracellular Membrane-bounded Organelle
Molecular Function
Chromatin Binding
RNA Binding
RNA Helicase Activity
Helicase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Telomeric DNA Binding
RNA Binding
Protein Binding
Structural Constituent Of Nuclear Pore
Telomeric DNA Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Nuclear-transcribed MRNA Catabolic Process, Endonucleolytic Cleavage-dependent Decay
Nuclear-transcribed MRNA Catabolic Process
DNA Replication
DNA Repair
MRNA Export From Nucleus
Regulation Of Translational Termination
Dosage Compensation By Inactivation Of X Chromosome
Viral Process
Telomere Maintenance Via Semi-conservative Replication
Regulation Of Telomere Maintenance
Cell Cycle Phase Transition
Positive Regulation Of MRNA Catabolic Process
3'-UTR-mediated MRNA Destabilization
Histone MRNA Catabolic Process
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-1
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Nucleocytoplasmic Transport
Positive Regulation Of Translation
MRNA Transport
Pathways
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Attention deficit hyperactivity disorder (
32595297
)
Height (
31562340
)
Nodular sclerosis Hodgkin lymphoma (
29196614
)
Pulse pressure (
30578418
)
Interacting Genes
103 interacting genes:
ABHD16A
ACSS2
ATR
CSNK2B
DCP1A
DCP2
DXO
EIF3A
EIF3B
EIF4A3
EXOSC2
EXOSC4
GNPTG
HIRA
LSM8
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
NADSYN1
NDRG1
NDUFB10
PLEKHA5
PLEKHB2
POLR2A
PTEN
RHOXF2
RPRD2
SMG1
SMG5
STAU1
SUMO2
UPF2
UPF3A
UPF3B
XRN1
9 interacting genes:
ALYREF
APP
GSK3B
IFITM2
NXF1
PIGT
RBM8A
SMG1
UPF1
Entrez ID
5976
65110
HPRD ID
03254
09274
Ensembl ID
ENSG00000005007
ENSG00000169062
Uniprot IDs
A0A024R7L5
A0A024R7L8
B3KY55
Q92900
B3KUE7
Q9H1J1
PDB IDs
2GJK
2GK6
2GK7
2IYK
2WJV
2WJY
2XZO
2XZP
6EJ5
6Z3R
2L08
Enriched GO Terms of Interacting Partners
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