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UPF1 and MIR138-1
Data Source:
BioGRID
(unspecified method)
UPF1
MIR138-1
Description
UPF1 RNA helicase and ATPase
microRNA 138-1
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
P-body
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Exon-exon Junction Complex
Supraspliceosomal Complex
Nucleus
Cytoplasm
Molecular Function
Chromatin Binding
RNA Binding
RNA Helicase Activity
Helicase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Telomeric DNA Binding
MRNA Binding Involved In Posttranscriptional Gene Silencing
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Nuclear-transcribed MRNA Catabolic Process, Endonucleolytic Cleavage-dependent Decay
Nuclear-transcribed MRNA Catabolic Process
DNA Replication
DNA Repair
MRNA Export From Nucleus
Regulation Of Translational Termination
Dosage Compensation By Inactivation Of X Chromosome
Viral Process
Telomere Maintenance Via Semi-conservative Replication
Regulation Of Telomere Maintenance
Cell Cycle Phase Transition
Positive Regulation Of MRNA Catabolic Process
3'-UTR-mediated MRNA Destabilization
Histone MRNA Catabolic Process
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-1
Negative Regulation Of Cell Adhesion
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Gene Expression
Negative Regulation Of Cell Migration
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Osteoblast Proliferation
Gene Silencing By MiRNA
MiRNA Mediated Inhibition Of Translation
Negative Regulation Of Phosphatidylinositol 3-kinase Activity
Plasma Membrane Raft Assembly
Negative Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Inflammatory Response
Negative Regulation Of Nitric-oxide Synthase Activity
Negative Regulation Of Stress Fiber Assembly
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Response To Cytokine Stimulus
Negative Regulation Of Protein K63-linked Ubiquitination
Negative Regulation Of Sprouting Angiogenesis
Negative Regulation Of P38MAPK Cascade
Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Attention deficit hyperactivity disorder (
32595297
)
Schizophrenia (
30285260
)
Interacting Genes
103 interacting genes:
ABHD16A
ACSS2
ATR
CSNK2B
DCP1A
DCP2
DXO
EIF3A
EIF3B
EIF4A3
EXOSC2
EXOSC4
GNPTG
HIRA
LSM8
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
NADSYN1
NDRG1
NDUFB10
PLEKHA5
PLEKHB2
POLR2A
PTEN
RHOXF2
RPRD2
SMG1
SMG5
STAU1
SUMO2
UPF2
UPF3A
UPF3B
XRN1
67 interacting genes:
ADARB1
C1QBP
CPSF1
DARS1
DDX1
DDX21
DDX3X
DHX36
EIF2AK2
EPRS1
ERAL1
ESRP1
FAM98A
FAM98B
FUS
HNRNPA0
HNRNPA1
HNRNPA2B1
HNRNPA3
HNRNPF
HNRNPH1
HNRNPH2
HNRNPH3
HNRNPK
HNRNPL
HNRNPM
HNRNPR
IARS1
IGF2BP1
IGF2BP2
IGF2BP3
KARS1
LARP7
LIN28A
LRPPRC
MARS1
MATR3
NONO
NUDT16L1
NUDT21
PDCD11
PRMT1
PTBP1
PTBP3
PUM1
QARS1
RARS1
RBM14
RBM4
RTCB
SF3B1
SF3B2
SF3B3
SF3B4
SFPQ
SPOUT1
STRBP
SYNCRIP
TAF15
TENT2
TRA2A
TRA2B
U2SURP
UPF1
UTP20
YBX1
YBX3
Entrez ID
5976
406929
HPRD ID
03254
Ensembl ID
ENSG00000005007
ENSG00000207954
Uniprot IDs
A0A024R7L5
A0A024R7L8
B3KY55
Q92900
PDB IDs
2GJK
2GK6
2GK7
2IYK
2WJV
2WJY
2XZO
2XZP
6EJ5
6Z3R
Enriched GO Terms of Interacting Partners
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