CPSF3 and PAPOLA

Data Source:
HPRD (in vitro)

		CPSF3	PAPOLA
Description		cleavage and polyadenylation specific factor 3	poly(A) polymerase alpha
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Binding Endoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Metal Ion Binding	Magnesium Ion Binding RNA Binding Polynucleotide Adenylyltransferase Activity Protein Binding ATP Binding Manganese Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Cleavage MRNA 3'-end Processing By Stem-loop Binding And Cleavage MRNA Export From Nucleus MRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	MRNA Splicing, Via Spliceosome Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA 3'-end Processing Regulation Of MRNA 3'-end Processing RNA Polyadenylation
Pathways		Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs	mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs			Cordycepin Triphosphate 3-sulfino-L-alanine Triphosphoric acid
Diseases
GWAS			Carboplatin disposition in epthelial ovarian cancer ( 29367611) Copper levels ( 26025379) Metabolite levels ( 23823483) Number of stillbirths in continuous marriage ( 30188897)
Interacting Genes		9 interacting genes: CLP1 FAM107A HSPB1 MIR19A MIR19B1 MIR92A2 PAPOLA POLR2A YWHAG	6 interacting genes: CPSF1 CPSF3 FIP1L1 SMAD2 SNRPA YWHAE
Entrez ID		51692	10914
HPRD ID		05825	10407
Ensembl ID		ENSG00000119203	ENSG00000090060
Uniprot IDs		G5E9W3 Q9UKF6	A0A024R6J7 A0A024R6M3 A0A0C4DGK1 P51003
PDB IDs		2I7T 2I7V 6M8Q 6V4X
Enriched GO Terms of Interacting Partners?
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