POLG and SSBP1

Data Source:
HPRD (in vivo)

		POLG	SSBP1
Description		DNA polymerase gamma, catalytic subunit	single stranded DNA binding protein 1
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GO Annotations	Cellular Component	Mitochondrion Gamma DNA Polymerase Complex Protein-containing Complex Mitochondrial Nucleoid Terminal Bouton	Nucleus Mitochondrion Mitochondrial Matrix Nucleoid Mitochondrial Nucleoid Extracellular Exosome
	Molecular Function	Protease Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding 3'-5' Exonuclease Activity	Chromatin Binding Single-stranded DNA Binding RNA Binding Protein Binding
	Biological Process	DNA Metabolic Process DNA-dependent DNA Replication Mitochondrial DNA Replication Base-excision Repair, Gap-filling Aging Response To Light Stimulus Response To Gamma Radiation Response To Hyperoxia Cellular Response To Glucose Stimulus DNA Biosynthetic Process Nucleic Acid Phosphodiester Bond Hydrolysis	Mitochondrial DNA Replication DNA Unwinding Involved In DNA Replication Mitochondrion Organization Positive Regulation Of Helicase Activity Mitochondrion Morphogenesis Positive Regulation Of DNA Helicase Activity
Pathways			Transcriptional activation of mitochondrial biogenesis
Drugs
Diseases		Mitochondrial DNA depletion syndrome (MDS)
GWAS		Height ( 18193045) Menopause (age at onset) ( 22267201 26414677) Schizophrenia ( 28991256) Smoking status (ever vs never smokers) ( 30643258) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668)	Anorexia nervosa ( 23568457)
Interacting Genes		2 interacting genes: SSBP1 TTC3	10 interacting genes: CDK1 CKS1B CKS2 GCM2 LDB1 LGALS7 LGALS7B OTUD6A POLG YWHAQ
Entrez ID		5428	6742
HPRD ID		01438	02703
Ensembl ID		ENSG00000140521	ENSG00000106028
Uniprot IDs		E5KNU5 P54098	A4D1U3 B7Z268 Q04837
PDB IDs		3IKM 4ZTU 4ZTZ 5C51 5C52 5C53	1S3O 2DUD 3ULL
Enriched GO Terms of Interacting Partners?
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