POLG and TTC3

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		POLG	TTC3
Description		DNA polymerase gamma, catalytic subunit	tetratricopeptide repeat domain 3
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Gamma DNA Polymerase Complex Protein-containing Complex Mitochondrial Nucleoid Terminal Bouton	Nucleus Nucleoplasm Nucleolus Golgi Apparatus Cytosol
	Molecular Function	Protease Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding 3'-5' Exonuclease Activity	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding
	Biological Process	DNA Metabolic Process DNA-dependent DNA Replication Mitochondrial DNA Replication Base-excision Repair, Gap-filling Aging Response To Light Stimulus Response To Gamma Radiation Response To Hyperoxia Cellular Response To Glucose Stimulus DNA Biosynthetic Process Nucleic Acid Phosphodiester Bond Hydrolysis	Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination
Pathways
Drugs
Diseases		Mitochondrial DNA depletion syndrome (MDS)
GWAS		Height ( 18193045) Menopause (age at onset) ( 22267201 26414677) Schizophrenia ( 28991256) Smoking status (ever vs never smokers) ( 30643258) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668)	Eye color traits ( 20463881)
Interacting Genes		2 interacting genes: SSBP1 TTC3	9 interacting genes: AKT1 ATF7IP HSPB1 MIR7-1 POLG TTN UBE2D2 UBE2E3 UBE3A
Entrez ID		5428	7267
HPRD ID		01438	03773
Ensembl ID		ENSG00000140521	ENSG00000182670
Uniprot IDs		E5KNU5 P54098	P53804
PDB IDs		3IKM 4ZTU 4ZTZ 5C51 5C52 5C53
Enriched GO Terms of Interacting Partners?
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