POLE2 and AGFG1

Data Source:
BioGRID (two hybrid)

		POLE2	AGFG1
Description		DNA polymerase epsilon 2, accessory subunit	ArfGAP with FG repeats 1
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GO Annotations	Cellular Component	Nucleoplasm Epsilon DNA Polymerase Complex Nuclear Body Intracellular Membrane-bounded Organelle	Nuclear Pore Cytosol Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding	DNA Binding RNA Binding GTPase Activator Activity Protein Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA-dependent DNA Replication DNA Replication Initiation DNA Repair Telomere Maintenance Via Semi-conservative Replication Error-prone Translesion Synthesis	MRNA Export From Nucleus Multicellular Organism Development Spermatogenesis Cell Differentiation Positive Regulation Of GTPase Activity Membrane Organization
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Cladribine
Diseases
GWAS			Airway hyperresponsiveness ( 23984888) Asthma ( 31959851) Mild influenza (H1N1) infection ( 26379185)
Interacting Genes		19 interacting genes: AGFG1 BAIAP2L2 EEF1A1 ERG28 EXOSC4 KAT5 MAPRE1 PKM POLE POLE4 REL SAP18 SORBS3 TBX15 TLE1 TRIM27 UBQLN2 ZBED1 ZNF620	14 interacting genes: APC APP DNAJC5 EPS15 EPS15L1 ITSN1 MFHAS1 NYAP2 PKIA POLE2 RNF216 TRIM54 VAMP7 XPO1
Entrez ID		5427	3267
HPRD ID		16007	02918
Ensembl ID		ENSG00000100479	ENSG00000173744
Uniprot IDs		P56282	A0A0S2Z3Y3 A0A0S2Z3Z1 A0A0S2Z444 A0A0S2Z462 P52594
PDB IDs		2V6Z 5VBN	2D9L 2OLM 2VX8
Enriched GO Terms of Interacting Partners?
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