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POLE2 and ZBED1
Data Source:
BioGRID
(two hybrid)
POLE2
ZBED1
Description
DNA polymerase epsilon 2, accessory subunit
zinc finger BED-type containing 1
Image
GO Annotations
Cellular Component
Nucleoplasm
Epsilon DNA Polymerase Complex
Nuclear Body
Intracellular Membrane-bounded Organelle
Chromatin
Nucleus
Nucleoplasm
Centrosome
PML Body
Nuclear Membrane
Molecular Function
DNA Binding
DNA-directed DNA Polymerase Activity
Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Transcription Coregulator Activity
Transcription Coactivator Activity
Protein Binding
SUMO Transferase Activity
Identical Protein Binding
Sequence-specific DNA Binding
Metal Ion Binding
Protein Dimerization Activity
SUMO Ligase Activity
Sequence-specific Double-stranded DNA Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
DNA Replication
DNA-dependent DNA Replication
DNA Replication Initiation
DNA Repair
Telomere Maintenance Via Semi-conservative Replication
Error-prone Translesion Synthesis
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Viral Process
Negative Regulation By Host Of Viral Genome Replication
Positive Regulation Of Transcription By RNA Polymerase II
Protein Autosumoylation
Pathways
Recognition of DNA damage by PCNA-containing replication complex
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
DNA replication initiation
Activation of the pre-replicative complex
SUMOylation of chromatin organization proteins
Drugs
Cladribine
Diseases
GWAS
Interacting Genes
19 interacting genes:
AGFG1
BAIAP2L2
EEF1A1
ERG28
EXOSC4
KAT5
MAPRE1
PKM
POLE
POLE4
REL
SAP18
SORBS3
TBX15
TLE1
TRIM27
UBQLN2
ZBED1
ZNF620
55 interacting genes:
AMOTL2
ATRX
C1orf109
CCDC13
CDC37
CTNNAL1
DGCR6
EFHC1
FABP4
FAM124B
FANCG
FNDC11
GGACT
GORASP2
GPN1
GPSM1
KDM1A
KIFC3
KLHL40
LCN2
LNX1
LRRC20
MAD2L2
MAGEB2
MKKS
MLH1
MPST
MYO15B
NCDN
NIF3L1
NIP7
NTAQ1
NUDT18
PAX6
PIAS2
PICK1
POLE2
POLR1C
PRKAA1
PRKAR1A
PSAP
RENBP
RIN1
SORBS3
SPEF1
SSX2
SUMO2
TRAPPC2
TRAPPC2B
TRIML2
TTC23
TTR
UBE2I
UCHL5
USP2
Entrez ID
5427
9189
HPRD ID
16007
02170
Ensembl ID
ENSG00000100479
ENSG00000214717
Uniprot IDs
P56282
A0A024RBU4
O96006
PDB IDs
2V6Z
5VBN
2CT5
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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