AGFG1 and RNF216

Data Source:
HPRD (in vivo)

		AGFG1	RNF216
Description		ArfGAP with FG repeats 1	ring finger protein 216
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Pore Cytosol Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytosol Schaffer Collateral - CA1 Synapse Postsynaptic Endocytic Zone Glutamatergic Synapse
	Molecular Function	DNA Binding RNA Binding GTPase Activator Activity Protein Binding Metal Ion Binding	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	MRNA Export From Nucleus Multicellular Organism Development Spermatogenesis Cell Differentiation Positive Regulation Of GTPase Activity Membrane Organization	Apoptotic Process Viral Process Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination Protein Catabolic Process, Modulating Synaptic Transmission
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Airway hyperresponsiveness ( 23984888) Asthma ( 31959851) Mild influenza (H1N1) infection ( 26379185)
Interacting Genes		14 interacting genes: APC APP DNAJC5 EPS15 EPS15L1 ITSN1 MFHAS1 NYAP2 PKIA POLE2 RNF216 TRIM54 VAMP7 XPO1	30 interacting genes: AGFG1 BRCA1 CAPN15 FAM168A KIR2DL4 MAPK1 MORC3 OPTN RIPK1 RNF11 SUMO2 TLR3 TLR4 TLR5 TLR9 TNFAIP3 TRAF3 UBAC1 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L3 UBE2L6 USP5 YOD1 ZFAND2A
Entrez ID		3267	54476
HPRD ID		02918	15550
Ensembl ID		ENSG00000173744	ENSG00000011275
Uniprot IDs		A0A0S2Z3Y3 A0A0S2Z3Z1 A0A0S2Z444 A0A0S2Z462 P52594	A8K8N1 Q9NWF9
PDB IDs		2D9L 2OLM 2VX8
Enriched GO Terms of Interacting Partners?
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