POLE2 and BAIAP2L2

Data Source:
BioGRID (two hybrid)

		POLE2	BAIAP2L2
Description		DNA polymerase epsilon 2, accessory subunit	BAR/IMD domain containing adaptor protein 2 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Epsilon DNA Polymerase Complex Nuclear Body Intracellular Membrane-bounded Organelle	Nucleoplasm Cytosol Plasma Membrane Vesicle Membrane Cytoplasmic Vesicle Membrane Cell-cell Contact Zone Clathrin Complex
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding	Phospholipid Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA-dependent DNA Replication DNA Replication Initiation DNA Repair Telomere Maintenance Via Semi-conservative Replication Error-prone Translesion Synthesis	Plasma Membrane Organization Positive Regulation Of Actin Filament Polymerization Actin Filament Bundle Assembly Actin Crosslink Formation Membrane Organization Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs		Cladribine
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Cutaneous malignant melanoma ( 32341527)
Interacting Genes		19 interacting genes: AGFG1 BAIAP2L2 EEF1A1 ERG28 EXOSC4 KAT5 MAPRE1 PKM POLE POLE4 REL SAP18 SORBS3 TBX15 TLE1 TRIM27 UBQLN2 ZBED1 ZNF620	6 interacting genes: ABI3 FAM9B GABPB1 GLYCTK GRXCR1 POLE2
Entrez ID		5427	80115
HPRD ID		16007	07997
Ensembl ID		ENSG00000100479	ENSG00000128298
Uniprot IDs		P56282	Q6UXY1
PDB IDs		2V6Z 5VBN
Enriched GO Terms of Interacting Partners?
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