POLE2 and NID2

Data Source:
BioGRID (affinity chromatography technology)

		POLE2	NID2
Description		DNA polymerase epsilon 2, accessory subunit	nidogen 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Epsilon DNA Polymerase Complex Nuclear Body Intracellular Membrane-bounded Organelle	Extracellular Region Basement Membrane Extracellular Space Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA-dependent DNA Replication DNA Replication Initiation DNA Repair Telomere Maintenance Via Semi-conservative Replication Error-prone Translesion Synthesis	Cell Adhesion Cell-matrix Adhesion Extracellular Matrix Organization Basement Membrane Organization
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Laminin interactions Laminin interactions
Drugs		Cladribine
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 29875488) Body mass index ( 28892062) Craniofacial microsomia ( 26853712) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Lung cancer (smoking interaction) ( 24658283) Pulmonary function ( 17903307) Triglyceride levels ( 32203549 29403010) Waist-to-hip ratio adjusted for body mass index ( 26785701)
Interacting Genes		19 interacting genes: AGFG1 BAIAP2L2 EEF1A1 ERG28 EXOSC4 KAT5 MAPRE1 PKM POLE POLE4 REL SAP18 SORBS3 TBX15 TLE1 TRIM27 UBQLN2 ZBED1 ZNF620	24 interacting genes: ANKRD13D CCN3 COL13A1 COL1A1 COL4A1 ELN GNE HOXC8 HSPG2 KPRP KRTAP1-3 KRTAP10-3 KRTAP6-2 LAMC1 LCE1A MAML3 PITX1 PLSCR4 RBP3 SKIL TFG UNKL ZNF581 ZNF774
Entrez ID		5427	22795
HPRD ID		16007	05654
Ensembl ID		ENSG00000100479	ENSG00000087303
Uniprot IDs		P56282	Q14112
PDB IDs		2V6Z 5VBN
Enriched GO Terms of Interacting Partners?
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