HP and C1RL

Data Source:
HPRD (in vitro)

		HP	C1RL
Description		haptoglobin	complement C1r subcomponent like
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Specific Granule Lumen Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Tertiary Granule Lumen	Extracellular Space Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Antioxidant Activity Hemoglobin Binding	Serine-type Endopeptidase Activity
	Biological Process	Acute Inflammatory Response Receptor-mediated Endocytosis Defense Response Acute-phase Response Positive Regulation Of Cell Death Zymogen Activation Response To Hydrogen Peroxide Defense Response To Bacterium Neutrophil Degranulation Negative Regulation Of Oxidoreductase Activity Cellular Oxidant Detoxification Negative Regulation Of Hydrogen Peroxide Catabolic Process	Complement Activation, Classical Pathway Zymogen Activation Innate Immune Response
Pathways		Scavenging of heme from plasma Neutrophil degranulation
Drugs		Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 29875488 28240269) Cholesterol, total ( 25961943 20686565) Haptoglobin levels ( 22403646) Hemoglobin levels ( 32327693) LDL cholesterol ( 25961943 20686565) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Morning person ( 30696823) Parental lifespan ( 30642433) Plasma haptoglobin levels in type 2 diabetes ( 29572449) Total cholesterol levels ( 29403010) Urinary haptoglobin levels in type 2 diabetes ( 29572449)	Blood protein levels ( 30072576 29875488) Night sleep phenotypes ( 27126917)
Interacting Genes		21 interacting genes: ADAMTS4 APOA1 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL	2 interacting genes: HP SPP1
Entrez ID		3240	51279
HPRD ID		00772	07093
Ensembl ID		ENSG00000257017	ENSG00000139178
Uniprot IDs		A0A0C4DGL8 P00738 Q6PEJ8	F5GWF3 F5H7C8 Q6P672 Q9NZP8
PDB IDs		4WJG 4X0L 5HU6 6TB2
Enriched GO Terms of Interacting Partners?
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