HP and CD163

Data Source:
HPRD (in vivo)

		HP	CD163
Description		haptoglobin	CD163 molecule
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Specific Granule Lumen Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Tertiary Granule Lumen	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endocytic Vesicle Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Antioxidant Activity Hemoglobin Binding	Scavenger Receptor Activity Protein Binding
	Biological Process	Acute Inflammatory Response Receptor-mediated Endocytosis Defense Response Acute-phase Response Positive Regulation Of Cell Death Zymogen Activation Response To Hydrogen Peroxide Defense Response To Bacterium Neutrophil Degranulation Negative Regulation Of Oxidoreductase Activity Cellular Oxidant Detoxification Negative Regulation Of Hydrogen Peroxide Catabolic Process	Receptor-mediated Endocytosis Acute-phase Response
Pathways		Scavenging of heme from plasma Neutrophil degranulation	Scavenging of heme from plasma CD163 mediating an anti-inflammatory response
Drugs		Zinc chloride Zinc sulfate, unspecified form	Tetrachlorodecaoxide
Diseases
GWAS		Blood protein levels ( 29875488 28240269) Cholesterol, total ( 25961943 20686565) Haptoglobin levels ( 22403646) Hemoglobin levels ( 32327693) LDL cholesterol ( 25961943 20686565) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Morning person ( 30696823) Parental lifespan ( 30642433) Plasma haptoglobin levels in type 2 diabetes ( 29572449) Total cholesterol levels ( 29403010) Urinary haptoglobin levels in type 2 diabetes ( 29572449)	Creatine kinase levels ( 29403010) HDL cholesterol levels ( 28334899) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 29083408)
Interacting Genes		21 interacting genes: ADAMTS4 APOA1 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL	5 interacting genes: CSNK2B FCGR1A HP MYH9 PRKCA
Entrez ID		3240	9332
HPRD ID		00772	05708
Ensembl ID		ENSG00000257017	ENSG00000177575
Uniprot IDs		A0A0C4DGL8 P00738 Q6PEJ8	Q86VB7
PDB IDs		4WJG 4X0L 5HU6 6TB2
Enriched GO Terms of Interacting Partners?
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