CALR and SLC6A4

Data Source:
HPRD (in vivo)

		CALR	SLC6A4
Description		calreticulin	solute carrier family 6 member 4
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Extracellular Space Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Polysome Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Phagocytic Vesicle Membrane Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Endocytic Vesicle Lumen	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Endosome Membrane Endomembrane System Neuron Projection Membrane Raft Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane Serotonergic Synapse
	Molecular Function	Complement Component C1q Complex Binding DNA Binding RNA Binding MRNA Binding Integrin Binding Iron Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Carbohydrate Binding Ubiquitin Protein Ligase Binding Peptide Binding Hormone Binding Protein Folding Chaperone Androgen Receptor Binding Unfolded Protein Binding Chaperone Binding	Neurotransmitter Transmembrane Transporter Activity Serotonin:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Syntaxin-1 Binding Cocaine Binding Identical Protein Binding Metal Ion Binding Nitric-oxide Synthase Binding Actin Filament Binding Serotonin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of Transcription, DNA-templated Protein Folding Protein Export From Nucleus Cellular Calcium Ion Homeostasis Receptor-mediated Endocytosis Spermatogenesis Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Translation Protein Maturation By Protein Folding Cortical Actin Cytoskeleton Organization Endoplasmic Reticulum Unfolded Protein Response Response To Estradiol Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Testosterone Protein Localization To Nucleus Protein Folding In Endoplasmic Reticulum ATF6-mediated Unfolded Protein Response Regulation Of Meiotic Nuclear Division Response To Drug Glucocorticoid Receptor Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Phagocytosis Protein Stabilization Sequestering Of Calcium Ion Cardiac Muscle Cell Differentiation Negative Regulation Of Cell Cycle Arrest Cellular Response To Lithium Ion Cellular Senescence Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Trophoblast Cell Migration Positive Regulation Of NIK/NF-kappaB Signaling Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane Positive Regulation Of Dendritic Cell Chemotaxis	Response To Hypoxia Neurotransmitter Transport Response To Nutrient Memory Circadian Rhythm Response To Toxic Substance Positive Regulation Of Gene Expression Positive Regulation Of Serotonin Secretion Monoamine Transport Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Negative Regulation Of Synaptic Transmission, Dopaminergic Response To Estradiol Social Behavior Sodium Ion Transmembrane Transport Neurotransmitter Biosynthetic Process Vasoconstriction Response To Drug Sperm Ejaculation Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Organ Growth Brain Morphogenesis Serotonin Uptake Cellular Response To Retinoic Acid Cellular Response To CGMP Regulation Of Thalamus Size
Pathways		ER-Phagosome pathway Assembly of Viral Components at the Budding Site Scavenging by Class A Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class F Receptors ATF6 (ATF6-alpha) activates chaperone genes Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Serotonin clearance from the synaptic cleft
Drugs		Antihemophilic factor, human recombinant Tenecteplase Melatonin Lanoteplase Copper Calcium citrate Calcium Phosphate Lonoctocog alfa Moroctocog alfa Calcium phosphate dihydrate	Fluvoxamine Amphetamine Phentermine Tramadol Citalopram Benzatropine Venlafaxine Atomoxetine Amitriptyline Protriptyline Loxapine Meperidine Imipramine Fluoxetine Duloxetine Dextromethorphan Nortriptyline Amoxapine Fenfluramine Mazindol Trazodone Verapamil Paroxetine Trimipramine Minaprine Pseudoephedrine Cocaine Cyclobenzaprine Dopamine Sertraline Sibutramine Chlorpheniramine Doxepin Nefazodone Desipramine Escitalopram Dexfenfluramine Aripiprazole Clomipramine Ephedra sinica root MMDA Midomafetamine 4-Methoxyamphetamine Metamfetamine Nomifensine Zimelidine Amineptine Bicifadine Milnacipran OPC-14523 CRx-119 Amitifadine Lumateperone Mianserin Tesofensine Tapentadol Vilazodone Desvenlafaxine Dexmethylphenidate Serotonin Levomilnacipran Butriptyline Vortioxetine Dosulepin Nisoxetine Lorpiprazole Zotepine Dasotraline
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) Estimated glomerular filtration rate ( 31152163) Platelet count ( 32888494) Red blood cell traits ( 23222517)	Brain morphology (MOSTest) ( 32665545) Height ( 28552196)
Interacting Genes		50 interacting genes: APOB APP AR B2M CD1D F5 F8 FBN1 FGB GSC2 HLA-A HLA-C HLA-E ITGA2B ITGA3 ITGAV LPL LRIF1 LRP1 MAPK6 MBL2 MTNR1A NKX2-1 NR3C1 PDIA2 PDIA3 PLAT PLP1 PRF1 PTPN11 RNY1 RNY3 RNY4 SCARF1 SGTB SIRPA SLC2A1 SLC6A4 SMARCB1 SQSTM1 SUMO4 TAF1B TAPBP TF THBS1 TRIM21 TSHR UBE3A UPF2 VWF	6 interacting genes: CALR CANX GPM6B STX1A VAMP2 YBX1
Entrez ID		811	6532
HPRD ID		00169	01640
Ensembl ID		ENSG00000179218	ENSG00000108576
Uniprot IDs		P27797 V9HW88	B2R7Y7 P31645
PDB IDs		2CLR 3DOW 3POS 3POW 5LK5 5V90 6ENY	5I6X 5I6Z 5I71 5I73 5I74 5I75 6AWN 6AWO 6AWP 6AWQ 6DZV 6DZW 6DZY 6DZZ 6VRH 6VRK 6VRL 6W2B 6W2C
Enriched GO Terms of Interacting Partners?
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