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PLN and FKBP8
Data Source:
BioGRID
(two hybrid)
PLN
FKBP8
Description
phospholamban
FKBP prolyl isomerase 8
Image
GO Annotations
Cellular Component
Mitochondrion
Endoplasmic Reticulum
Membrane
Mitochondrial Membrane
Vesicle
Sarcoplasmic Reticulum Membrane
Perinuclear Region Of Cytoplasm
Calcium Ion-transporting ATPase Complex
Mitochondrion
Endoplasmic Reticulum
Cytosol
Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Mitochondrial Membrane
Protein-containing Complex
Molecular Function
Enzyme Inhibitor Activity
Protein Binding
ATPase Inhibitor Activity
Identical Protein Binding
Protein Homodimerization Activity
ATPase Binding
Peptidyl-prolyl Cis-trans Isomerase Activity
Protein Binding
Identical Protein Binding
Protein Folding Chaperone
Metal Ion Binding
Disordered Domain Specific Binding
Biological Process
Regulation Of The Force Of Heart Contraction
Calcium Ion Transport
Notch Signaling Pathway
Blood Circulation
Regulation Of Heart Contraction
Response To Zinc Ion
Negative Regulation Of Heart Rate
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Negative Regulation Of ATPase Activity
Response To Insulin
Response To Testosterone
Negative Regulation Of Catalytic Activity
Cardiac Muscle Tissue Development
Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Calcium Ion Transport
Negative Regulation Of Calcium Ion Transport
Relaxation Of Cardiac Muscle
Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Regulation Of Cardiac Muscle Cell Contraction
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process
Regulation Of Cardiac Muscle Cell Membrane Potential
Regulation Of The Force Of Heart Contraction By Cardiac Conduction
Negative Regulation Of Calcium Ion Import
Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Negative Regulation Of Calcium Ion Binding
Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
Regulation Of Relaxation Of Cardiac Muscle
Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum
Protein Peptidyl-prolyl Isomerization
Cell Fate Specification
Negative Regulation Of Protein Phosphorylation
Protein Folding
Apoptotic Process
Smoothened Signaling Pathway
Regulation Of Gene Expression
Viral Process
Dorsal/ventral Neural Tube Patterning
Positive Regulation Of BMP Signaling Pathway
Multicellular Organism Growth
Intracellular Signal Transduction
Camera-type Eye Development
Negative Regulation Of Apoptotic Process
Pathways
Ion homeostasis
Ion transport by P-type ATPases
Ub-specific processing proteases
Drugs
Diseases
GWAS
Atrial fibrillation (
28416818
30061737
)
Cardiac structure and function (
19584346
)
QRS complex (Sokolow-Lyon) (
27659466
)
QRS duration (
27577874
27659466
)
QT interval (
23166209
24952745
19305408
19305409
19587794
29874175
)
Resting heart rate (
27798624
)
Plasma parathyroid hormone levels (
30134803
)
Urinary potassium excretion (
31409800
)
Interacting Genes
64 interacting genes:
ARL13B
ASGR2
ATP2A1
ATP2A2
ATP6V0E1
BCL2L13
BIK
CD53
CLDN7
CLEC2D
CPLX4
CREB3
CREB3L1
DMPK
DVL3
EDA
ELOVL4
FAM209A
FKBP8
FNDC9
GJA8
GPR152
GPR37L1
GPX8
HIBADH
HSD17B13
KIR2DL3
LDLRAD1
LSMEM2
MFF
MFSD5
MGST2
MGST3
MS4A7
MTIF3
MUC1
PLPPR1
PPP1R3A
PRKACA
RTN3
S100A1
SAR1A
SDC3
SIT1
SLC14A2
SLC30A8
SLC34A2
SLC35C2
SLC39A2
SLN
SPACA1
SPAG4
STX1A
STX2
TMEM106C
TMEM179B
TMEM205
TMEM31
TMEM45A
TMEM45B
TMEM52B
TMEM79
TMEM86B
TMPRSS2
48 interacting genes:
ANKMY2
ARHGEF5
ARL13B
ATP13A2
BCL2
BCL2L1
BNIPL
CD79A
CIDEB
CLCN1
CXCR2
CYB561
CYBRD1
EBP
EGFR
ELOVL4
ERBB2
ERGIC3
FAM174A
FGF14
GPR37
JAGN1
MAPK14
MFSD14B
MTOR
PEX12
PLN
PPP3CA
PSMC1
PSMD2
RETREG3
RHBDD2
RHEB
SCN3B
SLC10A6
SLC35A5
SLC35B1
SMO
TERF1
TMEM14B
TMEM254
TMEM31
TMEM43
TMEM45B
TMEM80
TMX1
VHL
ZFPL1
Entrez ID
5350
23770
HPRD ID
01395
05327
Ensembl ID
ENSG00000198523
ENSG00000105701
Uniprot IDs
P26678
Q5R352
A0A024R7P2
B2R8G6
Q14318
PDB IDs
1K9N
1KCH
1PLN
1PLP
1PSL
1ZLL
2HYN
2AWG
2D9F
2F2D
2MF9
3EY6
5MGX
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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