FKBP8 and CLCN1

Data Source:
BioGRID (pull down, affinity chromatography technology)

		FKBP8	CLCN1
Description		FKBP prolyl isomerase 8	chloride voltage-gated channel 1
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GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Cytosol Membrane Integral Component Of Endoplasmic Reticulum Membrane Mitochondrial Membrane Protein-containing Complex	Plasma Membrane Integral Component Of Plasma Membrane Chloride Channel Complex Sarcolemma
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Identical Protein Binding Protein Folding Chaperone Metal Ion Binding Disordered Domain Specific Binding	Voltage-gated Chloride Channel Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Protein Peptidyl-prolyl Isomerization Cell Fate Specification Negative Regulation Of Protein Phosphorylation Protein Folding Apoptotic Process Smoothened Signaling Pathway Regulation Of Gene Expression Viral Process Dorsal/ventral Neural Tube Patterning Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intracellular Signal Transduction Camera-type Eye Development Negative Regulation Of Apoptotic Process	Chloride Transport Muscle Contraction Neuronal Action Potential Propagation Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways		Ub-specific processing proteases	Stimuli-sensing channels
Drugs
Diseases			Myotonia congenita, including: Autosomal dominant myotonia congenita (Thomsen disease); Autosomal recessive myotonia congenita (Becker disease); Fluctuating myotonia congenita; Myotonia levoir
GWAS		Plasma parathyroid hormone levels ( 30134803) Urinary potassium excretion ( 31409800)
Interacting Genes		48 interacting genes: ANKMY2 ARHGEF5 ARL13B ATP13A2 BCL2 BCL2L1 BNIPL CD79A CIDEB CLCN1 CXCR2 CYB561 CYBRD1 EBP EGFR ELOVL4 ERBB2 ERGIC3 FAM174A FGF14 GPR37 JAGN1 MAPK14 MFSD14B MTOR PEX12 PLN PPP3CA PSMC1 PSMD2 RETREG3 RHBDD2 RHEB SCN3B SLC10A6 SLC35A5 SLC35B1 SMO TERF1 TMEM14B TMEM254 TMEM31 TMEM43 TMEM45B TMEM80 TMX1 VHL ZFPL1	7 interacting genes: AHSA1 APPBP2 CIDEB FAM9B FKBP8 PRDM5 STIP1
Entrez ID		23770	1180
HPRD ID		05327	00320
Ensembl ID		ENSG00000105701	ENSG00000188037
Uniprot IDs		A0A024R7P2 B2R8G6 Q14318	P35523
PDB IDs		2AWG 2D9F 2F2D 2MF9 3EY6 5MGX	6COY 6COZ 6QV6 6QVB 6QVC 6QVD 6QVU
Enriched GO Terms of Interacting Partners?
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