FKBP8 and PEX12

Data Source:
BioGRID (two hybrid)

		FKBP8	PEX12
Description		FKBP prolyl isomerase 8	peroxisomal biogenesis factor 12
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Cytosol Membrane Integral Component Of Endoplasmic Reticulum Membrane Mitochondrial Membrane Protein-containing Complex	Peroxisome Peroxisomal Membrane Integral Component Of Peroxisomal Membrane Peroxisomal Importomer Complex
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Identical Protein Binding Protein Folding Chaperone Metal Ion Binding Disordered Domain Specific Binding	Ubiquitin-protein Transferase Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Cell Fate Specification Negative Regulation Of Protein Phosphorylation Protein Folding Apoptotic Process Smoothened Signaling Pathway Regulation Of Gene Expression Viral Process Dorsal/ventral Neural Tube Patterning Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intracellular Signal Transduction Camera-type Eye Development Negative Regulation Of Apoptotic Process	Protein Monoubiquitination Protein Targeting To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Ubiquitination
Pathways		Ub-specific processing proteases	E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Plasma parathyroid hormone levels ( 30134803) Urinary potassium excretion ( 31409800)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		48 interacting genes: ANKMY2 ARHGEF5 ARL13B ATP13A2 BCL2 BCL2L1 BNIPL CD79A CIDEB CLCN1 CXCR2 CYB561 CYBRD1 EBP EGFR ELOVL4 ERBB2 ERGIC3 FAM174A FGF14 GPR37 JAGN1 MAPK14 MFSD14B MTOR PEX12 PLN PPP3CA PSMC1 PSMD2 RETREG3 RHBDD2 RHEB SCN3B SLC10A6 SLC35A5 SLC35B1 SMO TERF1 TMEM14B TMEM254 TMEM31 TMEM43 TMEM45B TMEM80 TMX1 VHL ZFPL1	36 interacting genes: ACSL5 ADIPOQ BNIP2 BTN2A2 C5orf46 CLDN10 COL8A2 CXCL16 CYBC1 DNAJC30 ERMP1 FA2H FKBP8 FXYD6 GJB2 IER3IP1 MARCHF2 MGLL NKG7 NRM PEX10 PEX19 PEX5 PNLIPRP1 PTPN9 RBFA SEC22A SEC61G SMCO4 SRGN STX8 THSD7B TMEM11 TMEM222 TREX1 TTPA
Entrez ID		23770	5193
HPRD ID		05327	03455
Ensembl ID		ENSG00000105701	ENSG00000108733
Uniprot IDs		A0A024R7P2 B2R8G6 Q14318	O00623
PDB IDs		2AWG 2D9F 2F2D 2MF9 3EY6 5MGX
Enriched GO Terms of Interacting Partners?
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