PLEK and ACVR1

Data Source:
HPRD (in vivo)

		PLEK	ACVR1
Description		pleckstrin	activin A receptor type 1
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex Apical Part Of Cell Activin Receptor Complex BMP Receptor Complex
	Molecular Function	Protein Kinase C Binding Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Activin Receptor Activity, Type I Peptide Hormone Binding Protein Homodimerization Activity Cadherin Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding Protein Tyrosine Kinase Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Platelet Degranulation Vesicle Docking Involved In Exocytosis Integrin-mediated Signaling Pathway Positive Regulation Of Platelet Activation Negative Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Inositol-polyphosphate 5-phosphatase Activity Cell Projection Organization Positive Regulation Of Actin Filament Depolymerization Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Cortical Actin Cytoskeleton Organization Ruffle Organization Actin Cytoskeleton Reorganization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Integrin Activation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Phosphatidylinositol Metabolic Process Negative Regulation Of Calcium-mediated Signaling Regulation Of Cell Diameter Thrombin-activated Receptor Signaling Pathway Platelet Aggregation Protein Kinase C Signaling Protein Secretion By Platelet	G1/S Transition Of Mitotic Cell Cycle Angiogenesis Branching Involved In Blood Vessel Morphogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Mesoderm Formation Neural Crest Cell Migration Acute Inflammatory Response Embryonic Heart Tube Morphogenesis Outflow Tract Septum Morphogenesis Atrioventricular Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion Morphogenesis Endocardial Cushion Fusion Atrial Septum Primum Morphogenesis Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Determination Of Left/right Symmetry Heart Development Dorsal/ventral Pattern Formation Negative Regulation Of Signal Transduction Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Ossification Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Smooth Muscle Cell Differentiation Pharyngeal System Development Pathway-restricted SMAD Protein Phosphorylation Ventricular Septum Morphogenesis Cardiac Muscle Cell Fate Commitment BMP Signaling Pathway Involved In Heart Development Endocardial Cushion Cell Fate Commitment Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Platelet degranulation
Drugs			ATP Dorsomorphin Fostamatinib
Diseases			Fibrodysplasia ossificans progressiva (FOP)
GWAS		Anger ( 24489884) Basophil count ( 32888494) Celiac disease ( 20190752) Lymphocyte counts ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 19043545) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 22190364 24076602 21833088) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Venous thromboembolism ( 31420334) White blood cell count ( 32888494)	Severe gingival inflammation ( 28459102)
Interacting Genes		4 interacting genes: ACVR1 INPP5A RHOU TGFBR1	70 interacting genes: AP2B1 BAMBI BMP2 BMP6 BMP7 BMPR1A BMPR2 CDK14 CHN1 CREBBP DCAF6 DUSP13 ENG FANCL FBXO30 FBXO7 FCHO1 FGD6 FKBP4 FNTA GDF2 GDF5 IGSF1 IKBKB INHBA INHBB INHBC KLHL35 NEK8 NKIRAS1 NRAS NUAK2 OTUB1 PAK1 PLEK PLEKHB1 PLEKHJ1 RAB17 RAB25 RAB33B RAB3B RAB6B RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 RXRA SMAD1 SMAD5 SMAD9 SOCS6 STIP1 STX8 TDGF1 TGFBR1 TGFBR2 THRB TTC17 TTC27 UBA52 UBE2E3 UBXN1 USP39 VDR VEPH1 WDR61
Entrez ID		5341	90
HPRD ID		15935	00021
Ensembl ID		ENSG00000115956	ENSG00000115170
Uniprot IDs		P08567	D3DPA4 Q04771
PDB IDs		1PLS 1W4M 1X05 1XX0 1ZM0 2CSO 2I5C 2I5F	3H9R 3MTF 3OOM 3Q4U 4BGG 4C02 4DYM 5OXG 5OY6 6ACR 6EIX 6GI6 6GIN 6GIP 6I1S 6JUX 6SRH 6SZM 6T6D 6T8N 6TN8 6Z36 6ZGC 7A21
Enriched GO Terms of Interacting Partners?
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