PLEK and INPP5A

Data Source:
HPRD (in vitro)

		PLEK	INPP5A
Description		pleckstrin	inositol polyphosphate-5-phosphatase A
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane	Plasma Membrane Membrane Dendrite
	Molecular Function	Protein Kinase C Binding Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding	Inositol-polyphosphate 5-phosphatase Activity Protein Binding PH Domain Binding Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity
	Biological Process	Hematopoietic Progenitor Cell Differentiation Platelet Degranulation Vesicle Docking Involved In Exocytosis Integrin-mediated Signaling Pathway Positive Regulation Of Platelet Activation Negative Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Inositol-polyphosphate 5-phosphatase Activity Cell Projection Organization Positive Regulation Of Actin Filament Depolymerization Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Cortical Actin Cytoskeleton Organization Ruffle Organization Actin Cytoskeleton Reorganization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Integrin Activation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Phosphatidylinositol Metabolic Process Negative Regulation Of Calcium-mediated Signaling Regulation Of Cell Diameter Thrombin-activated Receptor Signaling Pathway Platelet Aggregation Protein Kinase C Signaling Protein Secretion By Platelet	Inositol Phosphate Metabolic Process Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Inositol Phosphate-mediated Signaling Negative Regulation Of Neuron Death
Pathways		Platelet degranulation	Synthesis of IP2, IP, and Ins in the cytosol
Drugs
Diseases
GWAS		Anger ( 24489884) Basophil count ( 32888494) Celiac disease ( 20190752) Lymphocyte counts ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 19043545) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 22190364 24076602 21833088) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Venous thromboembolism ( 31420334) White blood cell count ( 32888494)	Gait speed in old age ( 28077804) Heel bone mineral density ( 30598549 28869591) Migraine ( 27182965) Primary sclerosing cholangitis ( 27992413) Pulse pressure ( 30578418) Systolic blood pressure ( 30224653 30578418) Triglyceride levels ( 32203549) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 30275531)
Interacting Genes		4 interacting genes: ACVR1 INPP5A RHOU TGFBR1	3 interacting genes: PLEK TEAD2 YWHAZ
Entrez ID		5341	3632
HPRD ID		15935	02521
Ensembl ID		ENSG00000115956	ENSG00000068383
Uniprot IDs		P08567	Q14642
PDB IDs		1PLS 1W4M 1X05 1XX0 1ZM0 2CSO 2I5C 2I5F
Enriched GO Terms of Interacting Partners?
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