ATP6V1E1 and ALDOB

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		ATP6V1E1	ALDOB
Description		ATPase H+ transporting V1 subunit E1	aldolase, fructose-bisphosphate B
Image		No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Endosome Cytosol Microvillus Apical Plasma Membrane Proton-transporting Two-sector ATPase Complex Proton-transporting Two-sector ATPase Complex, Catalytic Domain Extracellular Exosome	Microtubule Organizing Center Cytosol Centriolar Satellite Extracellular Exosome
	Molecular Function	Protein Binding Proton-exporting ATPase Activity, Phosphorylative Mechanism Hydrolase Activity Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding	Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Identical Protein Binding ATPase Binding Fructose-1-phosphate Aldolase Activity Fructose Binding
	Biological Process	Insulin Receptor Signaling Pathway Regulation Of Macroautophagy Transferrin Transport Ion Transmembrane Transport Phagosome Acidification Proton Transmembrane Transport	Fructose Metabolic Process Gluconeogenesis Glycolytic Process NADH Oxidation Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of ATPase Activity Canonical Glycolysis Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Vacuolar Proton-transporting V-type ATPase Complex Assembly
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport	Hereditary fructose intolerance Glycolysis Gluconeogenesis Fructose catabolism
Drugs		Tiludronic acid	1,6-Fructose Diphosphate (Linear Form) sn-glycerol 3-phosphate Dihydroxyacetone phosphate
Diseases			Hereditary fructose intolerance; Fructosemia
GWAS			Age-related cataracts ( 25352737) Liver enzyme levels (alkaline phosphatase) ( 22001757) Serum alkaline phosphatase levels ( 29403010)
Interacting Genes		14 interacting genes: ALDOA ALDOB ALDOC APP ATP6V0E1 ATP6V1G1 ATP6V1G2 ATP6V1H HSPB2 MESD SLC9A3R1 SOS1 TRAF6 XRCC6	22 interacting genes: AGXT2 ALDOA APP ATP6V1E1 BMPR1A BUB1 CDKN2A CTNNA1 DCC FLCN HIVEP1 HSPA8 MAP2K4 MCC MLH1 MLH3 MUC20 NRAS SMAD4 SRC STK11 TXN2
Entrez ID		529	229
HPRD ID		00163	01972
Ensembl ID		ENSG00000131100	ENSG00000136872
Uniprot IDs		P36543 Q53Y06	A0A024R145 P05062
PDB IDs			1QO5 1XDL 1XDM
Enriched GO Terms of Interacting Partners?
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