ALDOB and MLH3

Data Source:
BioGRID (two hybrid)

		ALDOB	MLH3
Description		aldolase, fructose-bisphosphate B	mutL homolog 3
Image			No pdb structure
GO Annotations	Cellular Component	Microtubule Organizing Center Cytosol Centriolar Satellite Extracellular Exosome	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex
	Molecular Function	Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Identical Protein Binding ATPase Binding Fructose-1-phosphate Aldolase Activity Fructose Binding	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATPase Activity Centromeric DNA Binding Mismatched DNA Binding
	Biological Process	Fructose Metabolic Process Gluconeogenesis Glycolytic Process NADH Oxidation Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of ATPase Activity Canonical Glycolysis Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Vacuolar Proton-transporting V-type ATPase Complex Assembly	Mismatch Repair Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Protein Localization
Pathways		Hereditary fructose intolerance Glycolysis Gluconeogenesis Fructose catabolism	Meiotic recombination
Drugs		1,6-Fructose Diphosphate (Linear Form) sn-glycerol 3-phosphate Dihydroxyacetone phosphate
Diseases		Hereditary fructose intolerance; Fructosemia	Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Age-related cataracts ( 25352737) Liver enzyme levels (alkaline phosphatase) ( 22001757) Serum alkaline phosphatase levels ( 29403010)	Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)
Interacting Genes		22 interacting genes: AGXT2 ALDOA APP ATP6V1E1 BMPR1A BUB1 CDKN2A CTNNA1 DCC FLCN HIVEP1 HSPA8 MAP2K4 MCC MLH1 MLH3 MUC20 NRAS SMAD4 SRC STK11 TXN2	45 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 NANS PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510
Entrez ID		229	27030
HPRD ID		01972	05094
Ensembl ID		ENSG00000136872	ENSG00000119684
Uniprot IDs		A0A024R145 P05062	Q2M1Z1 Q9UHC1
PDB IDs		1QO5 1XDL 1XDM
Enriched GO Terms of Interacting Partners?
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