LUC7L3 and TLR10

Data Source:
HPRD (two hybrid)

		LUC7L3	TLR10
Description		LUC7 like 3 pre-mRNA splicing factor	toll like receptor 10
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm U1 SnRNP Nuclear Speck U2-type Prespliceosome	Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	DNA Binding RNA Binding MRNA Binding Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	MRNA Splice Site Selection RNA Splicing	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Toll-like Receptor 10 Signaling Pathway Innate Immune Response Positive Regulation Of Inflammatory Response
Pathways			Toll Like Receptor 10 (TLR10) Cascade IRAK4 deficiency (TLR5) MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Mild to moderate chronic kidney disease ( 31178898)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Asthma ( 31361310 31959851 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Helicobacter pylori serologic status ( 23652523) Limited cutaneous systemic scleroderma ( 29293537) Self-reported allergy ( 23817569) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)
Interacting Genes		9 interacting genes: CLK1 ITSN2 MLH1 RNPS1 SRPK1 SRPK2 SRSF1 TLR10 YWHAG	12 interacting genes: CAT ECH1 F8A1 FLNA FUT7 GLDC LUC7L3 MYD88 PTPN6 TLR1 TLR2 TRIM54
Entrez ID		51747	81793
HPRD ID		16759	05884
Ensembl ID		ENSG00000108848	ENSG00000174123
Uniprot IDs		A8K3C5 J3KPP4 O95232 Q86Y74	A0A024R9W4 Q9BXR5
PDB IDs			2J67
Enriched GO Terms of Interacting Partners?
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