WBP11 and PQBP1

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		WBP11	PQBP1
Description		WW domain binding protein 11	polyglutamine binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Cytoplasmic Stress Granule Nuclear Body Nuclear Speck Neuronal Ribonucleoprotein Granule
	Molecular Function	Single-stranded DNA Binding RNA Binding Protein Binding WW Domain Binding	DNA Binding Double-stranded DNA Binding Transcription Coactivator Activity Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	MRNA Splicing, Via Spliceosome RRNA Processing MRNA Cis Splicing, Via Spliceosome	Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Regulation Of Transcription, DNA-templated Neuron Projection Development Positive Regulation Of Type I Interferon Production Regulation Of RNA Splicing Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Dendrite Morphogenesis Defense Response To Virus Cellular Response To Exogenous DsRNA
Pathways		mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway
Drugs
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Non-syndromic X-linked mental retardation
GWAS
Interacting Genes		32 interacting genes: APBB1 ARF1 C5orf22 CD2BP2 CTNNBL1 DDX17 DDX5 FYN GIGYF2 GRB2 ITSN1 MCRS1 MORN4 NCK2 NOD2 PIK3R1 PPP1CA PPP1CB PPP1CC PQBP1 PRPF40A RBM5 RTN4IP1 RUNX1T1 SEC23A SRC TESC TRAF4 TRIP10 UBASH3A VIM WBP4	24 interacting genes: APBB1 APP AQR ATXN1 CLTB EEF1A1 ERG28 ESR1 GOLGA2 HNRNPH2 LNX1 LRIF1 LZTS2 MAPRE1 MED31 POLR2A POU3F2 RAB8A RCVRN SFTPC TLX3 TXNL4A WBP11 WDR77
Entrez ID		51729	10084
HPRD ID		18293	02354
Ensembl ID		ENSG00000084463	ENSG00000102103
Uniprot IDs		A0A024RAW9 Q9Y2W2	A0A0S2Z4V5 O60828
PDB IDs			4BWQ 4BWS 4CDO
Enriched GO Terms of Interacting Partners?
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