WBP11 and ARF1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		WBP11	ARF1
Description		WW domain binding protein 11	ADP ribosylation factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Intracellular Membrane-bounded Organelle	Golgi Membrane Cytoplasm Late Endosome Peroxisomal Membrane Trans-Golgi Network Cytosol Plasma Membrane Focal Adhesion Postsynaptic Density Sarcomere COPI-coated Vesicle Cell Leading Edge Protein-containing Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Single-stranded DNA Binding RNA Binding Protein Binding WW Domain Binding	Magnesium Ion Binding RNA Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Phospholipase D Activator Activity
	Biological Process	MRNA Splicing, Via Spliceosome RRNA Processing MRNA Cis Splicing, Via Spliceosome	Regulation Of Receptor Internalization Phosphatidylinositol Biosynthetic Process Cellular Copper Ion Homeostasis Intracellular Protein Transport Actin Filament Organization Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Arp2/3 Complex-mediated Actin Nucleation Very-low-density Lipoprotein Particle Assembly Interleukin-12-mediated Signaling Pathway Positive Regulation Of Endocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Defense Response To Virus By Virus Positive Regulation Of Protein Secretion Regulation Of Catalytic Activity Golgi To Transport Vesicle Transport Long-term Synaptic Depression Positive Regulation Of Dendritic Spine Development Synaptic Vesicle Budding Dendritic Spine Organization Lysosomal Membrane Organization Cellular Response To Virus Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Late Endosome To Lysosome Transport Positive Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Phospholipid Metabolic Process Mitotic Cleavage Furrow Ingression
Pathways		mRNA Splicing - Major Pathway	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Nef Mediated CD4 Down-regulation trans-Golgi Network Vesicle Budding MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			1,3-Propanediol Guanosine-3'-monophosphate-5'-diphosphate Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate Brefeldin A Myristic acid Glycerin
Diseases
GWAS			Adolescent idiopathic scoliosis ( 31417091)
Interacting Genes		32 interacting genes: APBB1 ARF1 C5orf22 CD2BP2 CTNNBL1 DDX17 DDX5 FYN GIGYF2 GRB2 ITSN1 MCRS1 MORN4 NCK2 NOD2 PIK3R1 PPP1CA PPP1CB PPP1CC PQBP1 PRPF40A RBM5 RTN4IP1 RUNX1T1 SEC23A SRC TESC TRAF4 TRIP10 UBASH3A VIM WBP4	47 interacting genes: AGAP1 AGAP2 AP1B1 AP1G1 AP3B1 AP3D1 AP3S2 AP4E1 AP4M1 ARFGAP1 ARFIP1 ARFIP2 ARHGAP21 ASAP1 ASAP2 CHRM3 COPB1 COPE COPG1 CYTH1 CYTH2 DUX4 EEF1G ERBB2 GGA1 GGA2 GGA3 GORAB GOSR2 HTR2A INSR KDELR1 MDM4 NOA1 NPM1 PICK1 PIP5K1A PLD1 PLD2 PLEKHA8 PLIN2 RALA SCYL1 TMED10 TMED2 TMEM106A WBP11
Entrez ID		51729	375
HPRD ID		18293	00054
Ensembl ID		ENSG00000084463	ENSG00000143761
Uniprot IDs		A0A024RAW9 Q9Y2W2	A0A024R3Q0 P84077
PDB IDs			1HUR 1RE0 1U81 3O47 4HMY 6CM9 6CRI 6D83 6D84 6DFF 6FAE
Enriched GO Terms of Interacting Partners?
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