WBP11 and GIGYF2

Data Source:
HPRD (two hybrid)

		WBP11	GIGYF2
Description		WW domain binding protein 11	GRB10 interacting GYF protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Intracellular Membrane-bounded Organelle	Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoplasmic Stress Granule Membrane Protein-containing Complex Perikaryon Proximal Dendrite
	Molecular Function	Single-stranded DNA Binding RNA Binding Protein Binding WW Domain Binding	RNA Binding Protein Binding Cadherin Binding Proline-rich Region Binding
	Biological Process	MRNA Splicing, Via Spliceosome RRNA Processing MRNA Cis Splicing, Via Spliceosome	Posttranscriptional Gene Silencing Negative Regulation Of Translation Insulin-like Growth Factor Receptor Signaling Pathway MRNA Destabilization
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases			Parkinson's disease (PD)
GWAS			Anxiety and stress-related disorders ( 31116379) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 32469254 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Schizophrenia ( 25056061 29483656 23974872)
Interacting Genes		32 interacting genes: APBB1 ARF1 C5orf22 CD2BP2 CTNNBL1 DDX17 DDX5 FYN GIGYF2 GRB2 ITSN1 MCRS1 MORN4 NCK2 NOD2 PIK3R1 PPP1CA PPP1CB PPP1CC PQBP1 PRPF40A RBM5 RTN4IP1 RUNX1T1 SEC23A SRC TESC TRAF4 TRIP10 UBASH3A VIM WBP4	8 interacting genes: APC CNOT9 GRB10 GRB14 GRB7 RBM12 SNRPB WBP11
Entrez ID		51729	26058
HPRD ID		18293	11639
Ensembl ID		ENSG00000084463	ENSG00000204120
Uniprot IDs		A0A024RAW9 Q9Y2W2	Q6Y7W6
PDB IDs			5NVL 5NVM
Enriched GO Terms of Interacting Partners?
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